江西耐药结核病危险因素病例对照研究  

Case- control Study on Risk Factors of Drug- Resistant Tuberculosis in Jiangxi

作　　者：施少平[1] 刘睿[2] 王海清[1] 

机构地区：[1]宜春学院医学院 [2]宜春市疾病预防控制中心,江西宜春336000

出　　处：《宜春学院学报》2015年第9期55-56,82,共3页Journal of Yichun University

基　　金：江西省卫生厅科技计划项目(编号:20122035)

摘　　要：目的:了解江西继发性耐药结核病患者产生的主要社会行为危险因素。方法:用整群抽样方法抽取2012年1月至2014年5月在江西省宜春市及赣州市结核病防治所就诊的患者,治疗后仍然为DS-TB的结核病患者212例作为病例组,按年龄和性别1:1配对,与同期治疗全愈的患者进行对照。采用问卷形式调查患者可能导致继发性耐药的社会行为危险因素,并对其危险因素进行Logistic分析,并评价它们之间的关联程度。结果:江西省ADR-TB产生的主要危险因素为治疗不彻底,患者在治疗中依从性差和治疗过程有中断,治疗过程中经常饮酒,其调整的OR值及可信区间分别为7.85(5.632-14.024),5.532(3.356-9.275),4.673(2.357-9.746),2.278(1.642-3.412)。结论:加强对原发性结核病患者治疗期间的督导和管理,对降低ADR-TB的产生具有重要意义。Objective： To find out main social behaviour risk factors of secondary drug- resistant tuberculosis（ DR- TB） in Jiangxi. Methods： By cluster sampling method,we chose 212 patients as the case group from Yichun city and Ganzhou city of Jiangxi Province,who received treatment from January,2012 to May and still suffered from DS- TB. The group was contrasted with the cured patients paired 1： 1 by age and sex,who received treatment at the same period. The questionnaire survey was conducted to investigate the possible social risky behaviour that may cause the secondary DR- TB,and the Logistic analysis was done to the risk factors to appraise their correlation degree. Results： The main risk factor of ADR- TB in Jiangxi Province is the non- thorough treatment,low compliance of the patient,the break- off in the course of treatment and frequent drinking of alcohol; its adjustment OR value and the credible sector are respectively 7. 85（ 5. 632- 14. 024）,5. 532（ 3. 356- 9. 275）,4. 673（ 2. 357- 9. 746）,2. 278（ 1. 642- 3. 412）. Conclusions： It is of great significance to strengthen the supervision and management on the primary tuberculosis patient to reduce ADR- TB generation.

关 键 词：结核病 耐药 危险因素 

分 类 号：R181[医药卫生—流行病学]