生物钟基因与睡眠障碍的相关进展  

Research on Clock Genes and Sleep Disorders

作　　者：蔡玉芳[1] 王秀[1] 朱洁[2] 

机构地区：[1]皖南医学院,安徽芜湖241000 [2]安徽中医药大学,合肥230038

出　　处：《宜春学院学报》2015年第9期69-71,共3页Journal of Yichun University

基　　金：安徽省高校自然科学计划研究项目(KJ2013Z160;KJ2008B074)

摘　　要：昼夜节律是内源性的生物钟基因通过自身的转录、翻译和调控形成的以24小时为变动周期的一种生理现象。正常生理性睡眠是由睡眠稳态系统和生物钟系统共同维系的,当生物钟系统的功能紊乱时,必然会导致睡眠结构的破坏。生物钟由许多基因组成,如Clock,Pers,Cry等基因。研究表明,睡眠障碍与这些生物钟基因紧密相关。一般情况下,在生物钟基因的调节下,机体的生理和行为得以正常进行。而当生物钟基因发生突变或昼夜节律紊乱后,可导致睡眠障碍的发生。Circadian rhythm is endogenous clock genes through its own transcription,translation and regulation in 24 hours for the change cycle of a physical phenomenon. Normal physiologic sleep consists of sleep and circadian clock system to maintain the steady state system,when the clock system dysfunction,structural damage will inevitably result in a sleep. Clock is composed of many genes,such as Clock,Pers,Cry genes,etc. Studies have been shown that sleep disorders closely related to these clock genes. In general,under the regulation of circadian clock genes,the body＇s normal physiology and behavior. When the clock genes mutate or circadian rhythm in disorder,sleep disorders will occur.

关 键 词：生物钟基因 睡眠障碍 Per基因 CRY基因 

分 类 号：R34[医药卫生—基础医学]