气相色谱-质谱联用法同时测定除螨类化妆品中乐杀螨和克螨特  

Simultaneous determination of binapacryl and propargite in acaricidal cosmetics by GC-MS

作　　者：周静[1] 周泽琳[1] 顾宇翔[1] 冷桃花[1] 徐红斌[1] 周耀斌[1] 

机构地区：[1]上海市质量监督检验技术研究院,上海200233

出　　处：《日用化学工业》2015年第11期653-656,共4页China Surfactant Detergent & Cosmetics

基　　金：国家质量监督检验检疫总局科技计划资助项目(2014QK1537)

摘　　要：建立了除螨类化妆品中乐杀螨和克螨特的气相色谱-质谱联用（GC-MS）分析方法。样品用乙腈提取,基体分散固相萃取净化,经弱极性毛细管柱（HP-5MS）分离,选择特征离子监测扫描模式（SIM）测定,采用基质匹配标准溶液外标法定量。结果表明,乐杀螨和克螨特在6.0~40.0 mg/kg的范围内方法线性关系良好,相关系数R2≥0.995;乐杀螨和克螨特的检出限均为2.0 mg/kg,定量限均为6.0 mg/kg;在6.0和40.0 mg/kg质量分数下,乐杀螨和克螨特的精密度和重复性相对标准偏差均小于5%;在添加量为6.0,20.0和40.0 mg/kg时,乐杀螨的加标回收率为76.2%~93.1%,克螨特的加标回收率为77.2%~95.0%。An analysis method was established for the simultaneous determination of binapacryl and propargite in acaricidal cosmetics using gas chromatography-mass spectrometry（ GC-MS）. Samples were extracted by acetonitrile and purified with matrix solid-phase dispersion extraction（ MSPD）. The purified extracts were separated by weak polar capillary column（ HP-5MS） and components were detected with selected ion monitoring（ SIM） scanning mode. Quantification was carried out using matrix-matched standard curve calibration. The results showed that when the mass fraction of binapacryl and propargite is in the range of6. 0-40. 0 mg / kg,the content data displays good linear relationship with the response of the instrument and the correlation coefficients（ R2） are all more than 0. 995. The limits of detection of binapacryl and propargite are all 2. 0 mg / kg and the limits of quantification are all 6. 0 mg / kg. Under condition of mass fraction of 6. 0and 40. 0 mg / kg,all RSD of data of precisions and repeatability for binapacryl and propargite are less than5%. Values of spiked recoveries tested with addition of binapacryl on the levels of 6. 0,20. 0 and 40. 0 mg / kg are found to be from 76. 2% to 93. 1%. The spiked recoveries of propargite on the same levels are from77. 2% to 95. 0%.

关 键 词：化妆品 气相色谱-质谱联用法 乐杀螨 克螨特 

分 类 号：O657.63[理学—分析化学] TQ658[理学—化学]