天然孕激素对绝经早期妇女骨密度的影响  

Effect of natural progesterone on bone mineral density in early postmenopausal women

作　　者：暴蕾[1] 王国庆 叶连红[1] 范秀芳[1] 

机构地区：[1]陕西省西安市第四医院妇产科,710004 [2]陕西省肿瘤医院妇瘤科

出　　处：《山西医药杂志》2015年第22期2612-2614,共3页Shanxi Medical Journal

摘　　要：目的探讨天然孕激素对绝经早期妇女骨密度的影响。方法通过患者的知情同意,将60例子宫内膜癌术后患者按内膜癌组织孕激素受体阳性与否将其分为2组:试验组30例,给予微粒化孕酮(20mg/d)、钙剂(600mg/d)及维生素D(125U/d)治疗6个月,对照组30例,给予钙剂(600mg/d)及维生素D(125U/d)治疗6个月。观察2组治疗前、治疗3个月后及治疗6个月后体质量指数(BMI)、尿素氮(BUN)、肌酐(Cr)、血丙氨酸氨基转移酶(ALT)、血甘油三酯(TG)、骨密度值及骨代谢指标血清碱性磷酸酶(ALP)的变化。结果试验组及对照组用药前后BMI、BUN、Cr及血ALT差异均无统计学意义(P>0.05)。试验组及对照组在治疗前、治疗3个月后及治疗6个月后TG差异均无统计学意义(P>0.05)。在治疗前后试验组足跟部BMD与对照组相比,差异无统计学意义(P>0.05)。治疗3个月后,试验组及对照组足跟部BMD与治疗前相比,差异无统计学意义(P>0.05)。治疗6个月后,试验组及对照组足跟部BMD较治疗3个月后均显著升高(P<0.05)。在治疗前,试验组及对照组ALP值差异无统计学意义(P>0.05)。在治疗3个月及6个月后,试验组及对照组ALP值均有升高,并且在治疗后试验组ALP值显著高于对照组(P<0.05)。结论绝经早期孕酮联合维生素D及钙比单纯给予维生素D及钙在骨形成方面效果更好,而在改善骨密度方面效果不显著。Objective To investigate the effect of natural progesterone on bone mineral density in early postmenopausal women.Methods After endometrial cancer surgery,60 patients,who were informed,were divided into two groups according to endometrial carcinoma progesterone receptor positive or not.In the experimental group,30 patients took micronized progesterone 20 mg,calcium 600 mg and vitamin D 125 Ueveryday for 6months.In the control group,30 patients took calcium 600 mg and vitamin D 125 Ueveryday for 6months.Body mass index（BMI）,blood urea nitrogen（BUN）,creatinine（Cr）,blood alanine aminotransferase（ALT）,blood triglycerides（TG）,bone mineral density（BMD）and bone metabolism index alkaline phosphatase（ALP）in these patients were measured before and after the treatment of 3 months and 6 months respectively.Results BMI,BUN,Cr and blood alanine aminotransferase（ALT）of experimental treatment group and control group were of no significant difference before and after the treatment（P0.05）.Compared to control group,the TG of experimental group was not statistically significant before the treatment,3months after the treatment and 6months after the treatment（P0.05）.Compared to control group,the heel BMD of experimental group was not statistically significant before and after the treatment（P0.05）.Compared to the time before treatment,the heel BMD of experimental group and control group were not statistically significant after 3months of treatment（P0.05）.The heel BMD of experimental group and control group were increased significantly after 6 months of treatment than 3months of treatment.Before the treatment,the ALP value of experimental group and control group was of no significant difference（P0.05）.After 3months of treatment and 6month of treatment,the ALP values of experimental group and control group were both increased,and the ALP value of experimental group was significantly higher than that of the control group（P0.05）.Conclusion Compared to taking calcium and vitamin D simp

关 键 词：孕激素类 骨密度 绝经期 

分 类 号：R580[医药卫生—内分泌]