GATA-4在心肌损伤修复中的作用机制研究进展  

Research Progress of Role of GATA-4 in Cardiac Injury Repair

作　　者：贺继刚[1] 严丹[1] 王平[1] 李洪荣[1] 

机构地区：[1]云南省第一人民医院心脏大血管外科,昆明650000

出　　处：《医学综述》2015年第22期4033-4036,共4页Medical Recapitulate

基　　金：国家自然科学基金(81460073);云南省科技厅-昆明医科大学应用基础研究联合专项资金(2014FB089)

摘　　要：GATA-4是调控心脏基因表达的重要转录因子,参与了心脏正常发育、功能基因表达和心肌肥大的病理过程。GATA-4在心脏发育的早期起重要作用,抑制胚胎干细胞中GATA-4的表达可阻断胚胎干细胞向心肌细胞分化,增强GATA-4的表达则增加胚胎干细胞向心肌细胞分化。并且GATA-4还具有抗细胞凋亡的作用,GATA-4在心肌肥大期间成体心肌细胞的凋亡过程中具有重要的作用。通过增加促存活基因的表达,可改善细胞的存活。其在心肌损伤修复、缺血性心脏病治疗等方面成为目前研究的热点。GATA-4 is an important transcription factor. It can regulate cardiac gene expression and is involved in the normal development of the heart, expression of function gene and the pathological process of cardiac hypertrophy. In early heart development, GATA-4 plays an important role. Inhibiting GATA-4 expres- sion can block the differentiation of embryonic stem cells into cardiomyocytes, while enhancing GATA-4 expression can increase myocardial differentiation. In addition, there is considerable evidence that GATA-4 plays an important role in adult cardiomyocyte apoptosis with cardiac hypertrophy. Through increased expres- sion of pro-survival genes,cell survival can be improved. It has become a hot spot in cardiac repair,and treat- ment of ischemic heart disease.

关 键 词：GTTA-4 心肌细胞分化 分子机制 GTTA-4 

分 类 号：R392.11[医药卫生—免疫学]