橘核质量标准的优化研究  

Optimization of Quality standard of Citrus reticulata Blanco Semen

作　　者：黄天山 王晓清 罗嘉琪[1] 王淑美[1] 孟江[1] 于江泳[3] 梁生旺[1] 

机构地区：[1]广东药学院中药学院/国家中医药管理局中药数字化质量评价技术重点研究室/广东高校中药质量工程技术研究中心,广东广州510006 [2]郑州澍青医学高等专科学校药学系,河南郑州450000 [3]国家药典委员会,北京100050

出　　处：《广东药学院学报》2015年第5期607-611,共5页Academic Journal of Guangdong College of Pharmacy

基　　金：国家中医药管理局中医药行业科研专项(201207004-7)

摘　　要：目的完善橘核药材的质量标准。方法采用2010年版《中国药典》中方法对橘核药材中的水分、灰分及浸出物进行测定,并对薄层鉴别的条件及指标成分的高效液相色谱测定条件进行了优化。结果测定橘核药材中水分不得超过7.0%,总灰分不得超过5.0%,95%乙醇热浸出物不得少于34.0%,橘核柠檬苦素质量分数不得低于0.49%、诺米林质量分数不得低于0.46%;薄层鉴别斑点清晰,易于识别。结论橘核药材的水分、灰分、浸出物、薄层鉴别、指标成分质量分数研究可为橘核药材质量标准的修订、提高提供方法与依据。Objective To optimize the quality standard and establish an HPLC fingerprint of Citrus reticulata Blanco Semen. Methods The moisture,ashes,and ethanol extracts of C. reticulata Blanco Semen were determined according to the Chinese Pharmacopoeia of 2010 edition,and the conditions of the TLC identification and HPLC were optimized. Results The moisture in C. reticulata Blanco Semen was less than7.0%,with the total ash within 5.0%. The 95% ethanol extract was not less than 34.0% by hot soak,and the contents of index components of limonin and nomilin were not less than 0.49% and 0.46%,respectively.The TLC identification spots were clear and easy to identify. Conclusion The results might be used as important indicators for the quality standards of the C. reticulata Blanco Semen.

关 键 词：橘核 质量标准 薄层鉴别 高相液相色谱法 

分 类 号：R284.1[医药卫生—中药学]