丙肝病毒基因组、免疫逃逸及其疫苗研究进展  

Progress on the genome,immune-evasion and vaccines of hepatitis C virus

作　　者：张成成[1] 张立[2] 张文军[1,3] 

机构地区：[1]广东药学院基础学院,广东广州510006 [2]中山大学中山眼科中心,广东广州510060 [3]武汉大学病毒学国家重点实验室,湖北武汉430072

出　　处：《广东药学院学报》2015年第5期682-687,共6页Academic Journal of Guangdong College of Pharmacy

基　　金：中国博士后科研基金(2013M540601)

摘　　要：丙型肝炎标准疗法(So C)及一些新型抗病毒药物的应用,存在治疗效果欠佳,费用昂贵,副作用多等问题。随着生物技术的不断发展和完善,丙肝病毒疫苗的研制取得了重大进展。虽然目前还没有一种疫苗能够直接应用于临床,但是丙肝病毒疫苗在治疗和预防丙肝方面仍有巨大的前景。本文将重点阐述HCV基因组结构及特点、相关免疫逃逸机制以及一些颇具前景的候选疫苗。Standard-of-care（ So C） therapy and new antiviral agents for hepatitis C are inadequate and expensive with lots of side effects. Great progress has been made on the HCV vaccine with the development of biotechnology. Although there is no HCV vaccine that can be directly used in the clinical treatment at present,we still have great therapeutic and prophylactic prospect on HCV vaccine. In this review,we will mainly discuss the characteristics of the HCV gene,related immune mechanisms of escape and promising HCV vaccine candidates.

关 键 词：丙肝病毒 基因组 免疫逃逸 疫苗 

分 类 号：R392-33[医药卫生—免疫学]