手术切除和曲安奈德注射联合^(90)Sr-^(90)Y敷贴治疗瘢痕疙瘩的临床疗效观察  

Clinical observation of the therapeutic efficacy of surgical excision combined with triamcinolone acetonide injection and ^(90)Sr-^(90)Y applicator brachytherapy for the treatment of keloids

作　　者：曹春育[1] 帅茂圣 丁忠旗[2] 陈斯泰[1] 赵建林[1] 

机构地区：[1]泰州市人民医院皮肤科,江苏泰州225300 [2]泰州市人民医院核医学科,江苏泰州225300

出　　处：《临床皮肤科杂志》2015年第12期813-815,共3页Journal of Clinical Dermatology

摘　　要：目的:探讨手术切除、曲安奈德注射联合^(90)Sr-^(90)Y敷贴治疗瘢痕疙瘩的疗效。方法:将61例瘢痕疙瘩患者随机分为试验组(31例)和对照组(30例),所有患者瘢痕均进行手术切除,切口缝合后即时注射曲安奈德,试验组在术后3 d内给予^(90)Sr-^(90)Y敷贴,隔日1次,共6次;术后随访12~24个月观察其疗效。结果:术后所有患者切口均甲级愈合,随访12~24个月,试验组和对照组治愈率分别为70.96%和43.33%,两组比较差异有统计学意义(P<0.05);试验组和对照组有效率分别为77.41%和53.33%,两组比较差异有统计学意义(P<0.05);试验组和对照组复发率分别为19.35%和43.33%,两组比较差异也有统计学意义(P<0.05)。结论:手术切除、曲安奈德注射联合^(90)Sr-^(90)Y敷贴治疗瘢痕疙瘩安全有效,是较为理想的治疗方法。Objective： To evaluate the the efficacy and safety of surgical excision combined with triamcinolone acetonide injection and 90Sr-90Y applicator brachytherapy for the treatment of keloids. Methods： Sixty-one patients with keloids were divided into the treatment group（n=31） and the control group（n=30） randomly. All the patients were given surgical excision, and the patients received intradermal injection of triamcinolone acetonide immediately following the surgery. The treatment group was treated with 90Sr-90Yapplicator brachytherapy once every two days for 6 times within 3 days after the surgery. All the patients were followed up for 12 to 24 months for the assessment of clinical efficacy. Results： All the incisions healed by first intention. After following up for 12 to 24 months, the cure rates of the treatment group and the control group were 70.96% and 43.33%, respectively, with a significant difference between the two groups（P〈0.05）. The effective rates of the treatment group and the control group were 77.41% and 53.33%, respectively, the difference between the two groups was sta- tistical significant（P〈0.05）. The recurrence rates of the treatment group and the control group were 19.35% and 43.33%,re- spectively, there was a significant difference between the two groups （P〈0.05）. Conclusion： Surgical excision and triamci- nolone acetonide injection combined with 90Sr-90Y applicator brachytherapy is effective and safe for the treatment of keloids.

关 键 词：瘢痕疙瘩 手术切除 曲安奈德 90Sr-90Y敷贴 

分 类 号：R619.6[医药卫生—外科学]