Quality assessment and dissolution profile comparison studies on 250-mg mefenamic acid tablets available in local market of Karachi  

作　　者：Farya Zafar Huma Ali Shabana Naz Shah Safila Naveed Shehla Siddiqui 

机构地区：[1]Faculty of Pharmacy,Ziauddin University [2]Martin Dow Pharmaceutical Pakistan Limited [3]Jinnah University for Woman Karachi

出　　处：《Journal of Chinese Pharmaceutical Sciences》2015年第10期673-677,共5页中国药学（英文版）

摘　　要：In the present study, we aimed to determine the quality of different brands(Test1–Test6) of mefenamic acid, which are commercially available in local market of Karachi, Pakistan. Various quality evaluation tests, including weight variation, hardness, thickness, friability, disintegration, assay and drug release, were carried out. Results were found to be in acceptable limits. Moreover, release profiles were compared using different dissolution media, such as phosphate buffer pH 6.8, 7.4 and biorelevant media(FaSSGF, FaSSIF, FeSSIF and SCoF). Release profiles at pH 6.8 and 7.4 were evaluated by one--way ANOVA, model-independent and model--dependent methods. Results of ANOVA showed that no significant difference was found among tester and reference brands(Test1–Test6). Similarly, all the brands were found to be best fitted with Weibull model.In the present study, we aimed to determine the quality of different brands（Test1–Test6） of mefenamic acid, which are commercially available in local market of Karachi, Pakistan. Various quality evaluation tests, including weight variation, hardness, thickness, friability, disintegration, assay and drug release, were carried out. Results were found to be in acceptable limits. Moreover, release profiles were compared using different dissolution media, such as phosphate buffer pH 6.8, 7.4 and biorelevant media（FaSSGF, FaSSIF, FeSSIF and SCoF）. Release profiles at pH 6.8 and 7.4 were evaluated by one--way ANOVA, model-independent and model--dependent methods. Results of ANOVA showed that no significant difference was found among tester and reference brands（Test1–Test6）. Similarly, all the brands were found to be best fitted with Weibull model.

关 键 词：Mefenamic acid One-way ANOVA Model-independent Model--dependent method Biorelevant media 

分 类 号：R927[医药卫生—药学]