环丙沙星治疗泌尿系感染有效性的系统评价  

Effectiveness of ciprofloxacin in the treatment of urinary tract infection:a systematic review

作　　者：谢清[1] 刘桦[1] 粱硕[1] 黄建权[1] 

机构地区：[1]航天中心医院药剂科,北京100049

出　　处：《临床药物治疗杂志》2015年第5期29-35,共7页Clinical Medication Journal

基　　金：国家科技支撑课题子课题(2013BAI06B04Y023070)

摘　　要：目的:采用meta分析的方法系统评价环丙沙星治疗泌尿系感染(UTI)的疗效。方法:采用循证医学的文献分析评价方法,计算机检索Cochrane Library、Medline、EMbase、Pub Med、中国科技期刊全文数据库、维普电子期刊全文数据库、万方数据库等文献数据库,采用Rev Man5.1进行meta分析。结果:笔者共纳入26个随机对照试验,共5 519例患者。Meta分析结果显示:环丙沙星治疗UTI的有效性与其他喹诺酮类的差别无统计学意义[RR=1.01,95%CI(0.97,1.06),P=0.6];与磺胺类抗菌药物的差别无统计学意义[RR=1.07,95%CI(0.98,1.17),P=0.11];与青霉素类、头孢类和氨基糖苷类抗菌药物的差别有显著性差异(P<0.05)。结论:目前研究证据表明,环丙沙星治疗泌尿系感染疗效确切,优于青霉素类、头孢类和氨基糖苷类,不低于磺胺类和其他喹诺酮类抗菌药物。Objective：To evaluate the effectiveness of ciprolfoxacin in the treatment of urinary tract infection （UTI）, a meta-analysis was conducted in the present study.Methods： Cochrane Library, Medline, EMbase, PubMed, CNKI, VIP database, Wan fang database were searched and meta-analysis was performed using RevMan 5.1.Results：26 RCT studies were included （n=5 519）. The analysis indicated that there were no signiifcant differences in effectiveness between ciprolfoxacin and other quinolone[RR=1.01,95%CI（0.97, 1.06）,P=0.6]; there were no signiifcant differences in effectiveness between ciprolfoxacin and sulfa[RR=1.07,95%CI（0.98, 1.17）,P=0.11]; there were signiifcant differences in effectiveness between ciprolfoxacin and penicillin, cephalosporins, aminoglycoside （P〈0.05）.Conclusion：The effectiveness of the treatment of urinary tract infection of ciprolfoxacin is better than that of penicillin, cephalosporin and aminoglycoside while no less than sulfa and other quinolone antibacterial drugs.

关 键 词：环丙沙星 泌尿系感染 META分析 随机对照试验 

分 类 号：R691[医药卫生—泌尿科学]