精神分裂症阳性和阴性症状患者奥氮平治疗疗效与血浆BDNF关系研究  

Association Study Between Olanzapine Effect and Plasma BDNF in Schizophrenia Patients with Positive or Negative Symptoms

作　　者：宋明芬[1] 章隆 董介正[2] 陈海萍[2] 陶云海[2] 朱春燕[2] 王晟东[1] 施剑飞[2] 

机构地区：[1]杭州市第七人民医院,分子生物学实验室,杭州310013 [2]杭州市第七人民医院,精神科,杭州310013

出　　处：《中国现代应用药学》2015年第11期1388-1392,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：杭州市科技发展计划项目重点专科专病科研攻关项目(20130733Q27,21030733Q26);浙江省自然科学基金(LQ13H090003);杭州市卫生科技计划重点项目(2014Z10)

摘　　要：目的研究阳性症状和阴性症状精神分裂症患者奥氮平治疗前后血浆BDNF水平的变化。方法按入组和排除标准分别募集阳性、阴性症状精神分裂症患者以及健康对照,2组精神分裂症患者均接受奥氮平治疗,治疗前后PANSS量表得分变化评价奥氮平治疗效果,ELISA法测定病例组治疗前后以及对照组血浆BDNF水平,并比较差异。结果阳性症状精神分裂症患者治疗前后PANSS得分与血浆BDNF水平均呈显著负相关(P<0.01);治疗前血浆BDNF明显低于对照组(P<0.01);奥氮平治疗效果为好或中的患者,治疗后血浆BDNF水平比治疗前显著升高(P<0.01),而治疗无效的患者,治疗前后血浆BDNF差异无统计学意义。阴性症状患者奥氮平治疗前后PANSS得分与血浆BDNF水平均无明显相关性,且治疗前后血浆BDNF水平差异无统计学意义。结论血浆BDNF可作为判断阳性症状精神分裂症患者奥氮平治疗是否有效的参考指标。OBJECTIVE To study the plasma BDNF levels in schizophrenia patients with positive or negative symptoms before and after olanzapine treatment. METHODS Schizophrenia patients with positive symptoms, schizophrenia patients with negative symptoms and healthy controls were recruited based on the criteria of inclusion and exclusion. The two groups of patients received olanzapine treatment. Positive and negative syndrome scale（PANSS） questionnaire was used to estimate the response to olanzapine treatment. Plasma BDNF levels from the healthy controls and two groups of schizophrenia patients before and after olanzapine treatment were determined by ELISA method. RESULTS Significant negative correlations were obtained between PANSS scores and plasma BDNF levels both before and after olanzapine treatment in the patients with positive symptoms（P〈0.01）. In this group, plasma BDNF levels before olanzapine treatment were significantly lower than those of healthy controls. Furthermore, good or median response to olanzapine treatment had obviously increase in plasma BDNF levels when compared to those before treatment, while BDNF levels were not enhanced significantly in treatment-resistant patients. Neither significant change of plasma BDNF levels nor significant correlation between PANSS scores and plasma BDNF levels was observed in schizophrenia patients with the negative symptoms before and after olanzapine treatment. CONCLUSION Plasma BDNF could serve as the index of treatment response of olanzapine in schizophrenia patients with the positive symptoms.

关 键 词：精神分裂症 阳性症状 阴性症状 血浆BDNF 奥氮平 

分 类 号：R969.4[医药卫生—药理学]