液液平衡手性萃取拆分的研究进展  

Progress on Enantioselective Liquid-Liquid Extraction

作　　者：熊晴[1] 王小平[1] 鲁梦霞 黄娟 童胜强[1] 

机构地区：[1]浙江工业大学,杭州310032 [2]浙江省兽药饲料监察所,杭州310020

出　　处：《中国现代应用药学》2015年第11期1408-1413,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金(21105090);浙江省高等学校中青年学科带头人攀登项目(pd2013031)

摘　　要：目的介绍液液平衡手性萃取拆分技术的基本原理,总结近年来液液平衡手性萃取拆分的研究进展。方法根据手性选择剂的分类,对近年来液液平衡手性萃取拆分的最新应用研究情况做了介绍。结果总结归纳了5大类手性选择剂的应用,包括过渡金属络合物、酒石酸衍生物、冠醚类、β-环糊精衍生物及金鸡纳碱类,并简要介绍了液液萃取拆分相关模型研究。结论液液平衡手性萃取拆分技术分离效果良好,适用性强,易于实现工业规模,有望成为制备型分离外消旋体化合物的先进技术。OBJECTIVE To introduce the principle of enantioselective liquid-liquid extraction, and to review the progress on enantioselective liquid-liquid extraction in recent years. METHODS The recent progress on enantioselective liquid-liquid extraction was systematically reviewed according to the classification of chiral selectors. RESULTS Five typical types of chiral selector were summarized, including transitional metal complexes, tartaric acid derivatives, crown ethers, β-cyclodextrin derivatives and cinchona alkaloids. Meanwhile, studies on modeling and reaction kinetics of this technique were mentioned. CONCLUSION Enantioselective liquid-liquid extraction is an ideal resolution technology for preparative enantioseparation of racemates due to its high separation efficiency and ease-to-be scaled up characteristics.

关 键 词：液液平衡手性萃取拆分 手性分离 手性试剂 研究进展 

分 类 号：R917[医药卫生—药物分析学]