补中益气汤合沙参麦冬汤加减联合化疗治疗非小细胞肺癌临床疗效观察  

Clinical effect of Modified Buzhongyiqi Tang plus Shashenmaidong Tang combined with chemotherapy on advanced non-small cell lung cancer

作　　者：周卫东[1,2] 刘元铃[3] 张雪 邹卫兵 谭为[5,6] 罗仁[1] 赵晓山[1] 

机构地区：[1]南方医科大学南方医院中医科、中医药学院,广州市510515 [2]江西省新余市人民医院中医科,338000 [3]广东省妇幼保健院,广州市511442 [4]哈尔滨市中医医院内一科,150000 [5]广东省人民医院(广东省医学科学院)中医科,广州市510080 [6]广东省老年老年医学研究所中医科,广州市510080

出　　处：《实用医学杂志》2015年第21期3597-3600,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金青年基金项目(编号:81302958);广东省中医药局项目(编号:20131102)

摘　　要：目的:观察补中益气汤合沙参麦冬汤加减治疗晚期非小细胞肺癌临床疗效。方法 :选择2011年1月至2014年10月间收治的经确诊的初治晚期非小细胞肺癌患者110例,分别入补中益气汤合沙参麦冬汤加减联合NP方案化疗组(观察组)和单纯NP方案化疗组(对照组),每组55例,入组患者接受2个疗程化疗。从治疗肿瘤效果、生存质量、药物毒性反应、中医治疗疗效4个方面评价补中益气汤合沙参麦冬汤加减联合化疗治疗非小细胞肺癌临床的临床疗效。结果:与对照组相比,观察组治疗肿瘤客观评价疗效差异无显著性(P>0.05),KPS评分、化疗药物所致的毒性反应和中医症状改善差异有显著性(P<0.05或P<0.01)。结论:补中益气汤合沙参麦冬汤加减治疗非小细胞肺癌,在提高患者的生存质量、减轻化疗的毒副反应、改善中医临床症状等方面具有临床意义。Objective To observe the effects of Buzhongyiqi Tang plus Shashenmaidong Tang （BTST） combined with chemotherapy on advanced non-small cell lung cancer （NSCLC）. Methods A total of 110 patients with confirmed diagnosis of advanced non-small cell lung cancer between January 2010 and October 2013 were divided to treatment group （BTST treatment combined with chemotherepy of NP regimen, n = 55） and control group （chemotherepy of NP regimen, n = 55） and all eligible patients received two cycles of chemotherapy at least. The clinical efficacy was evaluated by tumor body, Karnorfsky score, toxicity of the drug and improvement of traditional Chinese medicine （TCM） symptom after two cycles of chemotherapy. Results All patients were evaluable for efficacy. There were no significant differences in efficacy of tumor body between two groups. However, the KPS score, chemotherapy toxicity and improvement of TCM symptoms in treatment group had statistical significance when compared with those in control group （P 〈 0.05 or P 〈 0.01）. Conclusion BTST can improve the quality of life and relieve side and toxic effects and TCM symptoms for patients with advanced NSCLC.

关 键 词：癌 非小细胞肺 补中益气汤合沙参麦冬汤 生活质量 药物毒性反应 

分 类 号：R273[医药卫生—中西医结合]