前列腺素E(凯时)改善糖尿病大鼠周围神经传导速度研究  

Prostaglandin E(Kai Shi) to Improve Peripheral Nerve Conduction Velocity in Diabetic Rats

作　　者：孙世博[1] 刘宗武[2] 吴易航 

机构地区：[1]长春市中心医院干诊科,吉林长春130051 [2]吉林省人民医院心内科,吉林长春130021 [3]华中科技大学医学部,湖北武汉430074

出　　处：《糖尿病新世界》2015年第21期87-89,共3页Diabetes New World Magazine

摘　　要：目的探讨前列腺素E(凯时)改善糖尿病大鼠周围神经病变(DPN)作用,并通过观察不同时间点给药的治疗效果,从而探索凯时用于糖尿病周围神经病(DPN)的最佳治疗时间点。方法 1应用链脲佐菌素(STZ)腹腔注射造Ⅰ型糖尿病(DM)大鼠模型;2分组:正常对照组、糖尿病组、凯时治疗组,其中后两组又随机分为5个时间观察点(0周、2周、4周、8周、12周);3用尼高力肌电图机检测不同时间点每组大鼠坐骨神经运动及感觉神经传导速度。结果 1应用STZ腹腔注射可成功造模。2糖尿病大鼠4周时已经开始出现坐骨神经感觉运动传导速度减慢,并且随病程延长逐渐加重,即病损程度与病程呈正相关。3凯时具有明显的改善周围神经运动感觉传导速度的作用,在4周后不同时间点给药均可改善神经传导速度,给药时间越早,运动感觉神经传导速度改善越显著,治疗效果越好。结论指导临床治疗糖尿病周围神经病(DPN)的最佳治疗时间点,即在运动感觉神经传导速度刚刚开始减慢时给药治疗效果最佳,并可见延缓病程进展。Objective To investigate the effect of prostaglandin E（Kai Shi） on peripheral nerve lesions（DPN） in diabetic rats and to explore the best treatment time of for diabetic peripheral neuropathy（DPN） by observing the therapeutic effect of different time points.Methods 1,the application of streptozotocin（STZ）.element（STZ） intraperitoneal injection made in type 1 diabetes mellitus（DM） rats model; 2,divided into two groups： normal control group,diabetes group and Kay in the treatment group.The 2 group were randomly assigned for treatment of five time point（0 week,2 weeks,4 weeks,8 weeks and 12 weeks）; 3,with a Nicolet EMG machine detected at different time points in each group of rats sciatic nerve motor and sensory nerve conduction velocity.Results STZ was successfully used to make a successful model.II in diabetic rats at4 weeks have begun to sciatic nerve motor and sensory conduction velocity slowing,and as the disease aggravated,namely lesion degree and duration of illness was positively.In the 4 weeks,the effect of the sensory conduction velocity of peripheral nerve conduction velocity,which can improve the nerve conduction velocity,the sooner the time of administration,the more significant the motor sensory nerve conduction velocity,the better the treatment effect.Conclusion The best treatment time points for the clinical treatment of diabetic peripheral neuropathy（DPN）,that is,the effect of the treatment of the nerve conduction velocity of sensory nerve is the best,and can be seen to delay the progress of the disease.

关 键 词：糖尿病 周围神经病 坐骨神经传导速度 前列腺素E(凯时) 

分 类 号：R587.1[医药卫生—内分泌]