补肾活血方治疗少弱精子症的临床研究  

Effect of Bushenhuoxue prescription on oligoasthenospermia

作　　者：刘建国 孙大林[2] 金保方[2,3] 赵红乐 

机构地区：[1]陕西省中医医院男科,西安710003 [2]东南大学附属中大医院中西医结合男科,南京210009 [3]江苏省人民医院临床生殖医学中心,南京210029

出　　处：《中国性科学》2015年第11期85-88,共4页Chinese Journal of Human Sexuality

基　　金：国家自然科学青年基金(81403402);国家自然科学基金(81273760)

摘　　要：目的:观察补肾活血方对少弱精子症不育患者的临床疗效,并探讨其可能的作用机制。方法:依照入选标准,纳入少弱精子症不育患者85例,根据随机分成对照组(35例)和治疗组(50例)。对照组患者口服Vit E胶囊,100mg/次,2次/d;治疗组服用中药补肾活血方治疗,1剂/d。两组分别在治疗前以及治疗后6个月检测患者的精液量、精子浓度、前向运动精子比率、精浆超氧化物歧化酶和丙二醛,并观察配偶妊娠情况。结果:对照组用药后,其精液量、前向运动精子活动率、精浆SOD和MDA较治疗前均有明显改善(P<0.05);治疗组用药后,其精液量、精子浓度、前向运动精子比率、精浆SOD和MDA较治疗前均有显著改善(P<0.05),在改善患者的精子浓度、前向运动精子比率、精浆SOD、精浆MDA等方面均优于对照组(P<0.05)。结论:补肾活血方能显著改善少弱精子症患者的精液质量、精浆SOD和MDA。补肾活血方可能是通过降低生精环境的氧化应激损伤,改善精子质量,治疗少弱精子症不育患者。Objectives： To investigate the clinical efficacy and mechanism of Bushenhuoxue prescription on patients with oligoasthenospermia. Methods： According to the inclusion criteria, 85 patients were randomly as- signed to control group （35 cases） and treatment group （50 cases）. The control group received VitE capsule, 100mg once, bid. The treatment group was given Bushenhuoxue prescription every day. The semen volume, sperm concentration, ratio of forward motile sperm, seminal plasma superoxide dismutase （SOD） and malondialdehyde （MDA） before and 6 months after treatment were compared and the pregnancy status of their spouses was observed. Results： In the control group, the semen volume, ratio of forward motile sperm, seminal SOD and seminal MDA were significantly improved after treatment （ P 〈 0. 05 ）. In the treatment group, the semen volume, sperm concen- tration, ratio of forward motile sperm, seminal SOD and MDA were all significantly improved compared to pre - treatment （P 〈 0.05）. Besides, the improvements in the treatment group was larger than the control group （ P 〈 0. 05）. Conclusion： Bushenhuoxue prescription can obviously improve the seminal quality, seminal MDA and se- minal SOD of oligoasthenospermia patient. Bushenhuoxue prescription may treat oligoasthenospermia patients by re- ducing oxidative stress injury and improving seminal quality.

关 键 词：补肾活血方 氧化应激 超氧化物歧化酶 丙二醛 少弱精子症 

分 类 号：R698.2[医药卫生—泌尿科学]