HIF-1α在胃癌血管生成中的作用及其与胃癌复发和预后的关系  

The role of hypoxia-inducihle factor-1α(HIF-1α) in the angiogenesis of gastric cancer and its relationship with recurrence and prognosis of gastric cancer

作　　者：雷媛[1] 陈刚[1] 何映雪 杜凌[1] 

机构地区：[1]广西医科大学第四附属医院,545005

出　　处：《现代消化及介入诊疗》2015年第5期467-470,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的研究缺氧诱导因子-1α(HIF-1α)在胃癌血管生成中的作用及其与胃癌复发和预后的关系。方法回顾性分析2008年12月至2010年12月于我院病理检查确诊为胃癌的120例患者的临床资料,所有患者均进行胃根治性切除,依据术后肿瘤是否复发分为复发组(60例)和对照组(60例)。所有胃癌组织切片均进行血管内皮生长因子(VEGF)、CD34和HIF-1α测定。利用卡方检验和Spearman分析HIF-1α阳性率与胃癌病理特征的关系;利用Kaplan-Merier法和Log-rank检查患者生存情况;利用单因素和Cox回归模型分析影响胃癌术后的独立影响因素。结果复发组HIF-1α阳性率与胃癌分化程度等病理特征显著相关(P<0.05);复发组患者HIF-1α阳性率与VEGF表达阳性和微血管密度(MVD)相关(r=0.38和0.43,P<0.05);复发组的中HIF-1α阴性者的1、2、3年生存率显著高于HIF-1α阳性者的生存率,差异均具有统计学差异(P<0.05);HIF-1α是胃癌预后的独立的影响因素(OR=2.734,95%CI1.083-4.465)。结论 HIF-1α可在胃癌血管生成过程中发挥重要作用,与胃癌复发密切相关。Objective To explore the role of hypoxia-inducihle factor-1α（HIF-1α） in the angiogenesis of gastric cancer and its relationship with recurrence and prognosis of gastric cancer. Methods A total of 120 pathology-proven cases of gastric cancer from December 2008 to December 2010 treated at our institute were included in this study. All patients were received curative gastrectomy and were divided into recurrent group （60 cases） and control group （60 cases） on the basis of whether the tumor recurrence after surgery. The expres-sions of HIF-1α, CD34 and vascular endothelial growth factor （VEGF） in the gastric tissue section of recur-rence group and control group were detected. Chi-square test and Spearman correlation analysis were per-formed for the correlation analysis between the positive rates of HIF-1α and clinical pathological features. Kaplan-Meier method and Log-rank test were used for the analysis of survival condition in recurrence group. The independent prognostic factors of gastric cancer were analyzed by univariate analysis and Cox regression model. Results The positive rate of HIF-1αexpression was highly correlated with the pathological features of gastric cancer such as pathological differentation （P〈0.05）. The positive rate of HIF-1αexpression of recur-rence group was closely correlated with the positive expression of VEGF and microvascular density （MVD） （r=0.38 and 0.43, both P〈0.05）. The one-year, two-year, and three-year survival rate of patients with negative HIF-1αexpression were significantly higher than that of patients with positive expression. HIF-1αexpression was independent prognostic factor of gastric cancer （OR=2.734,95%CI 1.083-4.465）. Conclusions The ex-pression of HIF-1αmay play an important role in the angiogenesis of gastric cancer and is closely related with gastric cancer recurrence.

关 键 词：HIF-1Α 胃癌 复发 预后 

分 类 号：R651.2[医药卫生—外科学]