他汀类药物对持续性心房颤动电复律后复发影响的荟萃分析  

Impact of statin therapy on recurrence of persistent atrial fibrillation after electrical cardioversion：a meta-analysis

作　　者：杨倩[1] 齐晓勇[1] 党懿[1] 宋学莲 郝潇[1] 

机构地区：[1]河北省人民医院心脏中心,石家庄050051

出　　处：《中华心血管病杂志》2015年第11期994-998,共5页Chinese Journal of Cardiology

摘　　要：目的评价他汀类药物对持续性心房颤动（AF）患者经电复律转复为窦性心律后复发的影响。方法检索PubMed、EMBase和Cochranecentralregisterofcontrolledtrials数据库，获取从建库至2015年2月发表的对比他汀类药物组与对照组电复律后AF复发率的随机对照试验。采用RevMan5．3和State12．0软件进行荟萃分析。结果纳入文献6篇，共572例患者。荟萃分析显示：持续性AF患者经电复律转复为窦性心律后，他汀类药物组与对照组之间的AF复发率差异无统计学意义（OR=0．60，95％C1：0．32-1．11，P〉0．05）；对纳入试验中应用阿托伐他汀治疗的4个试验进行亚组分析，结果显示他汀类药物组与对照组之间的电复律后AF复发率差异无统计学意义（OR=0．59，95％CI：0．25～1．39，P〉0．05）；对纳入试验中质量高的3个试验（Jadad评分≥3分）进行亚组分析，结果亦显示他汀类药物组与对照组之间的电复律后AF复发率差异无统计学意义（OR=0．76，95％CI：0．49～1．16，P〉0．05）。结论荟萃分析表明，持续性AF患者经电复律转复为窦性心律后，应用他汀类药物治疗对AF的复发无影响。Objective To evaluate the impact of statin therapy on the recurrence rate in patients with persistent atrial fibrillation （AF） after electrical eardioversion. Methods PubMed, EMBbase, Cochrane central register of controlled trials were searched up to February 2015 to identify randomized controlled trials, which reported the effect of statin therapy on AF recurrence after electrical cardioversion. The data were analyzed by RevMan 5.3 and Stata 12. 0 software. Results Six trials with 572 patients were included. The result showed that statin therapy had no effect on the recurrence rate in patients with persistent AF after electrical eardioversion （ OR = 0. 60,95 % CI：0. 32 - 1.11, P 〉 0. 05 ） compared with controls. Four out of the six trials investigated the effect of atorvastatin on the recurrence rate of AF after electrical cardioversion, subgroup analysis of these trials showed that compared with controls, atorvastatin had no effect on the recurrence of AF after electrical cardioversion （ OR = 0. 59,95% CI：0. 25 - 1.39, P 〉 0.05 ）. Three out of the six trials had high quality （ Jadad score ≥ 3 ）, subgroup analysis of these trials also showed that statins did not affect the recurrence rate of AF after electrical cardioversion （OR = 0.76,95% Cl：O. 49 - 1.16,P 〉 0. 05）. Conclusion This analysis suggested that statin therapy had no effect on the recurrence rate in patients with persistent AF after electrical cardioversion.

关 键 词：心房颤动 降血脂药 Meta分析 

分 类 号：R541.75[医药卫生—心血管疾病]