基于数据挖掘分析叶天士治疗胃脘痛的处方用药规律分析  

Rules of YE Tian-shi 's Prescriptions for Treating Stomachache Based on Data Mining

作　　者：唐林[1] 何倩[1] 李莉[1] 孟静岩[1] 

机构地区：[1]天津中医药大学,天津300193

出　　处：《中国实验方剂学杂志》2015年第22期229-233,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划(973计划)项目(2013CB531701)

摘　　要：目的:应用中医传承辅助平台软件,研究《叶天士医案大全》中治疗胃脘痛医案的处方用药规律。方法:收集、整理《叶天士医案大全》中治疗胃脘痛的处方,录入系统平台,并利用改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类等数据挖掘方法进行处方用药分析。结果:1对筛选出的治疗胃脘痛的105首处方进行分析,使用频次≥10次的药物有20味;2使用频次≥11次的常用药对有19个(支持度个数设为11),及得到药物关联规则(置信度设为0.6);3熵聚类得到的新核心药物组合14对,以及新处方7个;4以金铃子散进行方剂匹配,检索到包含金铃子散的20首处方的相似度。结论:通过中医传承辅助平台软件总结出叶天士治疗胃脘痛的用药规律,为深入了解和掌握叶氏遣方用药规律提供了数据支持。Objective： To analyze the rules of Ye Tian-shi＇s prescriptions for treating stomachache in Ye Tian-shi ＇s Medical Records by using traditional Chinese medicine inheritance support system（ TCMISS）.Method： The prescriptions for treating stomachache in YE Tian-shi＇s Medical Records were collected and then entered into TCMISS. The medication rules were analyzed by using data mining methods,including revised mutual information,complex system entropy cluster and unsupervised hierarchical clustering. Result： 1 Based on the analysis of 105 prescriptions,20 herbs were used for more than 10 times in the database. 219 herb pairs were used for 11 times,when the support degree was set to 11. Moreover,when the confidence was set to 0. 6,the association rules for the herbs in the prescriptions were obtained. 314 pairs of new core herbal combinations and 7new prescriptions were obtained by using entropy cluster and hierarchical clustering methods. 4The similarity of 20 prescriptions including Jinlingzi power was searched by matching prescriptions. Conclusion： The rules of Ye Tianshi＇s prescriptions for treating stomachache were summarized through TCMISS,which will provide the data support for in-depth studies on Ye＇s prescriptions.

关 键 词：叶天士 胃脘痛 中医传承辅助平台 数据挖掘 用药规律 

分 类 号：R287.6[医药卫生—中药学]