新疆维吾尔族和汉族原发性高血压病患者颈动脉内膜中层厚度与血清胱抑素C水平的关系  

Relationship Between Carotid Intima-media Thickness and Cys-C in Uygur and Han Patients With Essential Hypertension

作　　者：王黎[1] 陈曦[1] 张源明[1] 梁丽艳[1] 张邱兵 

机构地区：[1]新疆医科大学第一附属医院心脏中心高血压科,新疆乌鲁木齐市830000

出　　处：《中国全科医学》2015年第33期4049-4054,共6页Chinese General Practice

摘　　要：目的探讨新疆维吾尔族、汉族原发性高血压病患者颈动脉内膜中层厚度(IMT)与血清胱抑素C(Cys-C)水平的关系。方法回顾性分析2012年11月—2014年3月在新疆医科大学第一附属医院心脏中心高血压科住院的494例原发性高血压病患者的病历资料,其中维吾尔族197例,汉族297例。根据颈动脉IMT分组,将维吾尔族患者分为正常组100例和异常组97例,汉族患者分为正常组179例和异常组118例。收集患者入院时一般资料,检测并比较IMT正常与异常患者生化指标〔空腹血糖、Cys-C、三酰甘油、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)〕、颈动脉IMT及动态血压〔24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)〕。结果维吾尔族患者中,正常组与异常组年龄、Cys-C、24 h SBP比较,差异有统计学意义(P<0.05)。汉族患者中,正常组与异常组年龄、Cys-C比较,差异有统计学意义(P<0.05)。维吾尔族患者中,年龄、空腹血糖、Cys-C、24 h SBP与颈动脉IMT呈正相关(P<0.05);进一步校正年龄、空腹血糖、24 h SBP后,Cys-C仍与颈动脉IMT呈正相关(r=0.217,P=0.010)。汉族患者中,年龄、体质指数、24 h SBP与颈动脉IMT呈正相关,Cys-C与颈动脉IMT呈负相关(P<0.05);进一步校正年龄、体质指数、24 h SBP后,Cys-C仍与颈动脉IMT呈负相关(r=-0.163,P=0.038)。多因素Logistic回归分析结果显示,年龄、Cys-C是维吾尔族患者颈动脉IMT的影响因素,年龄是汉族患者颈动脉IMT的影响因素(P<0.05)。结论血清Cys-C水平升高是维吾尔族原发性高血压病患者颈动脉IMT增加的危险因素,而可能与汉族原发性高血压病患者颈动脉IMT无关。Objective To investigate the relationship between carotid intima-media thickness（ IMT） and Cystatin C（ Cys-C） level in Uygur and Han patients with essential hypertension. Methods We made a retrospective analysis of the data of the medical history of 494 patients who were admitted into the Department of Hypertension of the First Affiliated Hospital of Xinjiang Medical University from December 2012 to March 2014. Among the patients, 197 were Uygur and 297 were Han. According to the classification of carotid IMT,Uygur patients were divided into normal group（ n = 100） and abnormal group（ n = 97）,and Han peoples were also divided into normal group（ n = 179） and abnormal group（ n = 118）. The general data of the patients were collected at admission,and the biochemical indexes 〔fasting blood glucose（ FBG）,Cys-C,triacylglycerol（ TG）, total cholesterol（ TC）, high density lipoprotein cholesterol（ HDL-C）, low density lipoprotein cholesterol（ LDL-C） 〕 were examined and compared,carotid IMT and ambulatory blood pressure 〔24 h average systolic pressure（ 24 h SBP） and 24 h average diastolic pressure（ 24 h DBP） 〕. Results There were significant differences in age,Cys-C and24 h SBP between the two groups of Uygur patients（ P〈0. 05）, and there were significant differences in age and Cys-C between the two groups of Han patients（ P〈0. 05）. Among Uygur patients,carotid IMT was positively related with age,FBG,Cys-C and 24 h SBP（ P〈0. 05）; after further adjustment of age,FBG and 24 h SBP,Cys-C was still positively associated with carotid IMT（ r = 0. 217, P = 0. 010）. Among Han patients, carotid IMT was positively related with age, BMI and24 h SBP and was negatively related with Cys-C（ P〈0. 05）; after further adjustment of age,BMI and 24 h SBP,Cys-C was still negatively associated with Cys-C（ r =-0. 163,P = 0. 038）. Multivariate Logistic regression analysis showed that age and Cys-C were influencing factors for carotid IMT in Uygur patients,and ag

关 键 词：高血压 颈动脉内膜中膜厚度 抑素类 维吾尔族 汉族 

分 类 号：R544.11[医药卫生—心血管疾病]