前降支病变冠状动脉粥样硬化性心脏病患者接受经皮冠状动脉介入治疗对于侧支循环及心功能的影响研究  被引量:1

Influence of percutaneous coronary intervention on collateral circulation and heart function in coronary heart disease with anterior descending lesion

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作  者:郑进民 赵桂琴 李新 

机构地区:[1]南京明基医院心血管内科,210019

出  处:《中国医药》2015年第12期1742-1745,共4页China Medicine

摘  要:目的研究前降支病变冠状动脉粥样硬化性心脏病(冠心病)患者接受经皮冠状动脉介入治疗(PCI)对侧支循环及心功能的影响。方法选取2011年3月至2013年7月南京明基医院接受冠状动脉造影诊断为前降支单支病变的246例冠心病患者作为研究对象,根据侧支循环开放情况将患者分为侧支循环组(105例)和无侧支循环组(141例),侧支循环组患者再根据血流来源分为对侧侧支循环组(58例)、同侧+对侧侧支循环组(26例)、同侧侧支循环组(21例)。比较各组患者PCI治疗前后心功能指标[左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、B型钠尿肽(BNP)和红细胞体积分布宽度(RDW)]差异。结果侧支循环组和无侧支循环组患者在年龄、性别、高血压、糖尿病及吸烟史方面差异无统计学意义(P〉0.05)。侧支循环组与无侧支循环组患者术前及术后1、6个月心功能指标分别为[侧支循环组LVEF:(45.7±9.8)%、(46.6±0.4)%、(47.4±0.4)%.LVEDV:(48.36±6.82)、(48.67±0.28)、(53.12±0.32)ml,BNP:(6.32±1.59)、(5.72±0.08)、(5.59±0.07)ng/L,RDW:(14.59±1.68)%、(13.75±0.07)%、(13.56±0.13)%;无侧支循环组LVEF:(43.6±8.8)%、(45.4±0.3)%、(46.3±0.3)%,LVEDV:(48.51±5.36)、(48.87±0.26)、(55.36±0.38)ml,BNP:(6.39±1.27)、(6.21±0.09)、(6.05±0.06)ng/L,RDW:(14.86±1.87)%、(14.41±0.09)%、(13.76±0.12)%],2组患者术前各指标差异无统计学意义(P〉0.05),侧支循环组患者术后1个月的LVEF、BNP、RDW水平及术后6个月时的LVEF、BNP、LVEDV、RDW水平与无侧支循环组患者比较差异有统计学意义(P〈0.05)。对侧侧支循环组、同侧+对侧侧支循环组、同侧�Objective To explore the influence of percutaneous coronary intervention (PCI) on collateral circulation and heart function in coronary heart disease with anterior descending lesion. Methods Totally 246 patients of coronary heart disease with single-vessel of anterior descending lesion confirmed by coronary angiography from March 2011 to July 2013 were enrolled and divided into collateral circulation group (105 cases) and non-collateral circulation group ( 141 cases) ; the patients in collateral circulation group were divided into collateral circulation group (58 cases), ipsilateral + contralateral collateral circulation group (26 cases), and ipsilateral collateral circulation group (21 cases). The cardiac function indicators, including left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV), B type natriuretic peptide (BNP) and red blood cell volume distribution width (RDW) , were compared among groups. Results There were no significant differences between collateral circulation group and non-collateral circulation group regarding age, sex, hypertension, diabetes and smoking ( P 〉 0. 05 ). The cardiac function before operation, 1 and 6 months after operation in collateral circulation group were as followed: LVEF (45.7 ±9.8)%, (46.6 ±0.4)%, (47.4 ±0.4)%, LVEDV (48.36±6.82), (48.67 ±0.28), (53.12 ±0.32) ml, BNP (6.32 ±1.59), (5.72 ±0.08), (5.59 ±0.07) ng/L, RDW (14.59±1.68)%, (13.75 ±0.07)%, (13.56±0. 13)%; in non-collateral circulation group was as followed: LVEF (43.6±8.8)%, (45.4±0.3)%, (46.3±0.3)%, LVEDV (48.51 ±5.36), (48.87±0.26), (55.36 ±0.38) ml, BNP (6.39±1.27), (6.21 ±0.09), (6.05 ±0.06) ng/L, RDW ( 14. 86 ±1.87) % , ( 14. 41 ±0. 09 ) % , ( 13.76 ± 0. 12 ) %. Above indicators were not significantly different between groups; the levels of LVEF, BNP, RDW 1 month after operation, the levels of LVEF, BNP, L

关 键 词:冠状动脉疾病 前降支病变 经皮冠状动脉介入 侧支循环 心功能 

分 类 号:R541.4[医药卫生—心血管疾病]

 

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