骨龙胶囊联合盐酸氨基葡萄糖片治疗膝关节骨性关节炎的临床效果分析  

Effect of Gulong capsule combined with glucosamine hydrochloride tablet in treating knee osteoarthritis

作　　者：王志忠[1] 胡叶暖[1] 刘献旺 

机构地区：[1]北京军区总医院第三门诊部,100012

出　　处：《中国医药》2015年第12期1808-1810,共3页China Medicine

摘　　要：目的探讨骨龙胶囊联合盐酸氨基葡萄糖片治疗膝关节骨性关节炎（KOA）的临床效果。方法选取2013年3月至2015年5月于北京军区总医院第三门诊部和骨科门诊就诊的膝关节骨性关节炎患者68例，完全随机分为观察组和对照组，各34例。观察组给予骨龙胶囊2．5g，3次／d口服，盐酸氨基葡萄糖片240mg，3次／d口服；对照组给予盐酸氨基葡萄糖片240mg，3次／d口服。分别观察治疗前及治疗后60d2组患者的关节疼痛程度、关节肿胀、关节活动度、步行能力的变化并评分，比较2组患者治疗效果。结果治疗后，观察组总有效率88．2％（30／34），其中临床治愈3例、显效16例、有效11例、无效4例；对照组总有效率64．7％（22／34），其中临床治愈0例、显效9例、有效13例、无效12例，2组总有效率差异有统计学意义（P〈0．05）。2组患者不良反应程度均较轻微，差异无统计学意义（P〉0．05）。结论应用骨龙胶囊联合盐酸氨基葡萄糖片治疗膝关节骨性关节炎安全有效，能够缓解关节疼痛，提高患者的生活质最。Objective To explore the effect of Gulong capsule combined with glucosamine hydrochloride tablet in treating knee osteoarthritis （KOA）. nethords Totally 68 KOA patients from March 2012 to March 2015 were randomly divided into observation group （30 cases） orally given Gulong capsule （2. 5 g, 3 times/d） combined with glucosamine hydrochloride tablet （240 mg, 3 times/d） , and control group （34 cases） orally given glucosamine hydrochloride tablet （240 mg, 3 times/d oral）. Before and 60 days after treatment, the degree of arthralgia, arthroncus, range of motion and walking ability were assessed and graded; the eft）ctive rate and incidence of adverse reactions were compared between groups. Results In observation group, 3 cases were clinically cured, 16 cases were markedly effective, 11 cases were effective, 4 cases were ineffective; in control group, none was cured, 9 cases were markedly effective, 13 cases were effective, 12 cases were ineffective; the total effective rate in observation group was significantly higher than that in control group [ 88.2% （30/34） vs 64. 7% （22/34） ] （P 〈 0.05）. The adverse reaction degree was relatively mild in both groups; the incidence of adverse reactions was not significantly different between groups （ P 〉 0. 05 ）. Conclusion Gulong capsule combined with glucosamine hydrochloride tablets is safe and effective in treating KOA, it can relieve joint pain and improve the life quality.

关 键 词：膝关节骨性关节炎 骨龙胶囊 盐酸氨基葡萄糖片 

分 类 号：R684.3[医药卫生—骨科学]