尿毒清颗粒对终末期肾功能衰竭维持性血液透析患者钙磷代谢及甲状旁腺激素水平的影响  

Effect of Niaoduqing particles on calcium-phosphorus metabolism and parathyroid hormone in patients of end-stage renal failure with maintenance hemodialysis

作　　者：门雯瑾[1] 丁致民[1] 

机构地区：[1]北京积水潭医院肾内科,100035

出　　处：《中国医药》2015年第12期1818-1821,共4页China Medicine

摘　　要：目的探讨尿毒清颗粒对终末期肾功能衰竭维持性血液透析患者钙磷代谢及甲状旁腺激素水平的影响。方法选取2011年10月至2014年2月于北京积水潭医院血液净化中心进行血液透析治疗的终末期。肾功能衰竭患者62例，完全随机分为观察组和对照组，各31例。对照组常规行血液透析治疗；观察组在常规血液透析基础上口服尿毒清颗粒，1袋（5．0g）／次，4次／d。2组疗程均为6个月。比较2组患者治疗前后血钙、血磷及甲状旁腺激素水平，同时比较2组患者皮肤瘙痒缓解程度和不良反应发生情况。结果观察组治疗6个月后血钙高于治疗前[（2．24±0．17）mmol／L比（1．87±0．19）mmol／L]，血磷及甲状旁腺激素水平均低于治疗前[（1．53±0．14）mmol／L比（1．81±0．12）mmol／L，（202±40）ng／L比（244±42）ng／L]，差异均有统计学意义（均P〈0．05）。对照组治疗6个月后血钙水平高于治疗前[（2．11±0．16）mmol／L比（1．89±0．21）mmol／L]，血磷水平低于治疗前[（1．66±0．11）mmol／L比（1．82±0．13）mmol／L]，差异有统计学意义（P〈0．05），甲状旁腺激素水平与治疗前比较，差异无统计学意义[（238±43）ng／L比（244±42）ng／L]（P〉0．05）。治疗6个月后，观察组血钙水平高于对照组，血磷及甲状旁腺激素水平低于对照组，差异均有统计学意义（均P〈0．05）。观察组皮肤瘙痒症状总缓解牢明显高于对照组[83．9％（26／31）比51．6％（16／31）]，差异有统计学意义（x^2=7．485，P〈0．05）。所有患者均无发热、皮疹等过敏反应，无胃肠道、神经系统等严重不良反应。结论尿毒清颗粒对纠止终末期肾功能衰竭维持性血液透析患者钙磷代谢紊乱、降低甲状旁腺激素水平及改善皮肤瘙痒均有一定疗效。Objective To explore the effect of Niaoduqing particles on calcium-phosphorus metabolism and parathyroid hormone in patients of end-stage renal failure with maintenance hemodialysis. Methods Totally 62 patients with end-stage renal failure who underwent hemodialysis from October 2011 to February 2014 were randomly divided into observation group （ 31 cases） orally administrated with Niaoduqing particles （ 5.0 g/time, 4 times/d） in addition to routine hemodialysis, and control group （31 cases） given routine hemodialysis. The treatment was lasted for 6 months, then the changes of serum calcium, serum phosphate and parathyroid hormone （PTH） were detected and compared between the two groups, the degree of pruritus releasing and incidence of adverse reactions were also observed. Results After treatment, the level of serum calcium was significantly increased, the levels of serum phosphate and PTH were significantly reduced compared with those before treatment in observation group [ （2.24 ±0.17） mmol/L vs （ 1.87 ±0. 19） mmol/L, （ 1.53 ±0.14） mmol/L vs （ 1.81 ± 0.12） retool/L, （202 ±40） ng/L vs （244 ±42） ng/L] （P 〈0.05） ; after treatment, the level of serum calcium was significantly increased and the level of serum phosphate was significantly reduced compared with those before treatment in control group [（2. 11 ±0. 16） mmol/L vs （1.89±0.21） retool/L, （1.66 ±0. 11） mmol/L vs （ 1.82 ± 0.13 ） mmol/L] （P 〈 0.05 ）, while no change was found for PHT [ （238± 43 ） ng/L vs （244 ±42） ng/L] （ P 〉 0.05 ）. After treatment, the levels of serum calcium and PTH in observation group was significantly different with those in control group （ all P 〈 0.05 ）. The releasing rate of pruritus in observation group was significantly higher than that in control group [83. 9% （26/31） vs 51. 6% （16/31）] （x^2 =7. 485, P 〈0. 05）. No fever, allergic reaction such as rash, gastrointestinal and nervous severe adverse reactions were found. Conc

关 键 词：肾功能衰竭 尿毒清颗粒 血液透析滤过 钙磷代谢 甲状旁腺激素 

分 类 号：R692.5[医药卫生—泌尿科学]