Qualitative Analysis of Diagnostic Value of 24-h Proteinuria for Preeclampsia  

作　　者：Xu Zhuang Yun-Yan Chen Qiong Zhou Jian-Hua Lin 

机构地区：[1]Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

出　　处：《Chinese Medical Journal》2015年第22期2998-3002,共5页中华医学杂志（英文版）

摘　　要：Background： Preeclarnpsia （PE） is a serious idiopathic disease posing a threat to both mothers and fetuses＇ lives during pregnancy, whose main diagnostic criteria include hypertension with proteinuria. However, American College of Obstetricians and Gynecologists （ACOG） updated the diagnostic criteria for PE and redtlced the diagnostic value of proteinuria for patients with PE. Qualitative analysis of the diagnostic value of 24-h proteinuria for patients with PE in China was conducted to evaluate the diagnostic criteria value in the latest ACOG guideline. Methods： Complete clinical data of 65 patients with hypertensive disorder in pregnancy （HDP） were collected. All patients were delivered to and hospitalized in Renji Hospital. Adverse outcome was defined in case of the emergence of any serious complication for a mother or the fetus. A retrospective study was conducted according to ACOG guideline, to analyze the relationship between each diagnostic criteria of ACOG guideline and maternal and perinatal outcomes. Spearman correlation test was used to detect the association between each diagnostic criterion, its corresponding value, and the adverse pregnancy outcome. Logistic regression was performed to verily the result of Spearman correlation test. Results： Of 65 HDP patients, the percentage of adverse pregnancy outcome was 63.1%. Adverse pregnancy outcomes constitute diversification. There were 55 cases with 24-h proteinuria value ≥0.3 g, of which the adverse outcome rate was 74.5%. While adverse pregnancy outcomes did not appear in the rest 10 HDP patients with proteinuria 〈0.3 /24 h. The statistic difference was significant （P = 0.000）. However, no significant difference was tbund in other criteria groups （impaired liver function： P = 0.417; renal insufficiency： P = 0.194; thrombocytopenia： P - 0.079： and cerebral or visual symptoms： P = 0.296）. The correlation coefficient between 24-h proteinuria ≥0.3 g and adverse pregnancy outcomes was 0.557 （P 〈 0.005）. hnpaiBackground： Preeclarnpsia （PE） is a serious idiopathic disease posing a threat to both mothers and fetuses＇ lives during pregnancy, whose main diagnostic criteria include hypertension with proteinuria. However, American College of Obstetricians and Gynecologists （ACOG） updated the diagnostic criteria for PE and redtlced the diagnostic value of proteinuria for patients with PE. Qualitative analysis of the diagnostic value of 24-h proteinuria for patients with PE in China was conducted to evaluate the diagnostic criteria value in the latest ACOG guideline. Methods： Complete clinical data of 65 patients with hypertensive disorder in pregnancy （HDP） were collected. All patients were delivered to and hospitalized in Renji Hospital. Adverse outcome was defined in case of the emergence of any serious complication for a mother or the fetus. A retrospective study was conducted according to ACOG guideline, to analyze the relationship between each diagnostic criteria of ACOG guideline and maternal and perinatal outcomes. Spearman correlation test was used to detect the association between each diagnostic criterion, its corresponding value, and the adverse pregnancy outcome. Logistic regression was performed to verily the result of Spearman correlation test. Results： Of 65 HDP patients, the percentage of adverse pregnancy outcome was 63.1%. Adverse pregnancy outcomes constitute diversification. There were 55 cases with 24-h proteinuria value ≥0.3 g, of which the adverse outcome rate was 74.5%. While adverse pregnancy outcomes did not appear in the rest 10 HDP patients with proteinuria 〈0.3 /24 h. The statistic difference was significant （P = 0.000）. However, no significant difference was tbund in other criteria groups （impaired liver function： P = 0.417; renal insufficiency： P = 0.194; thrombocytopenia： P - 0.079： and cerebral or visual symptoms： P = 0.296）. The correlation coefficient between 24-h proteinuria ≥0.3 g and adverse pregnancy outcomes was 0.557 （P 〈 0.005）. hnpai

关 键 词：American College of Obstetricians and Gynecologists Guideline Hypertensive Disorders in Pregnancy PREECLAMPSIA Pregnancy Outcomes PROTEINURIA 

分 类 号：S852.32[农业科学—基础兽医学] S858.23[农业科学—兽医学]