3,6-二吡啶N-乙基咔唑的合成  

Syntheses of 9-Ethyl-3,6-di-pyridin-4-yl-9H-Carbazole

作　　者：潘兆瑞[1] 石翛然[1] 邵阳[1] 刘雪茹[1] 莫正靖 

机构地区：[1]南京晓庄学院环境科学学院,江苏南京211171

出　　处：《南京晓庄学院学报》2015年第6期7-9,共3页Journal of Nanjing Xiaozhuang University

基　　金：国家自然科学基金青年基金(基金号21301094);南京晓庄学院大学生科研项目(2015XSKY073);南京晓庄学院青年专项基金(2015NXY74)

摘　　要：该文以咔唑为原料,利用Suzuki偶联反应成功合成了3,6-二吡啶N-乙基咔唑.咔唑首先与溴乙烷发生取代反应生成N-乙基咔唑,然后与N-溴代丁二酰亚胺反应生成3,6-二溴代N-乙基咔唑,最后与吡啶-4-硼酸通过Suzuki偶联反应生成目标化合物.三步反应总收率为55.7%,并对目标产物进行了红外和核磁表征.In this paper, 9-Ethyl-3,6-di-pyridin-4-yl-gH-Carbazole was synthesized by the method of Suzuki cou- pling reaction with earbazole as raw materials. Firstly, N-ethyl earbazole was generated by the substitution reaction of Carbazole with bromine ethane, Then the obtained product reacted with N-bromosuccinimide and generated 3,6- dibromo-N-ethyl earbazole. Finally the target compound was obtained by Suzuki coupling reaction of 3,6-dibromo- N-ethyl carbazole with pyridine-4-borie acid. The total yield was 55.7% , and the target compound was character- ized with ^1H NMR.

关 键 词：咔唑 SUZUKI 偶联反应 3 6-二吡啶N-乙基咔唑 

分 类 号：O621.3[理学—有机化学]