吡拉西坦联合尼莫地平治疗血管性痴呆的临床观察  

Treatment analysis of piracetam combined with nimodipine in cerebral infarction after vascular dementia

作　　者：祁俐[1] 

机构地区：[1]沈阳市红十字会医院神经内科,辽宁110013

出　　处：《社区医学杂志》2015年第22期23-25,共3页Journal Of Community Medicine

摘　　要：目的分析吡拉西坦联合尼莫地平治疗血管性痴呆的临床效果及安全性。方法选取2014年2—8月收治的86例脑梗死后血管性痴呆患者作为研究对象,随机分为对照组和观察组各43例。对照组给予尼莫地平口服治疗,15~60 mg/次,2次/d;观察组在对照组的基础上给予吡拉西坦口服治疗,0.8 g/次,3次/d;两组均连续治疗6个月。比较两组临床疗效及简易精神状态量表（mini-mental state examination,MMSE）、日常生活活动（activities of daily living,ADL）评分变化情况。计量资料组间采用t检验,组内比较采用配对t检验,计数资料采用χ2检验,P〈0.05为差异有统计学意义。结果观察组治疗总有效率为86.04%,明显高于对照组的65.11%,差异有统计学意义（P〈0.05）。治疗后,观察组与对照组MMSE评分分别为（24.84±4.38）、（20.15±3.25）分,均高于治疗前的（16.37±3.05）、（16.38±3.14）分;ADL评分分别为（23.45±9.84）、（35.15±9.72）分,均低于治疗前的（38.20±9.71）、（38.15±10.04）分,差异均有统计学意义（均P〈0.05）。治疗后,观察组MMSE评分高于对照组,ADL评分低于对照组,差异均有统计学意义（均P〈0.05）。结论吡拉西坦联合尼莫地平治疗血管性痴呆效果显著,能明显改善患者认知及生活能力,且无明显不良反应,值得临床推广应用。Objective To observe the clinical effects of piracetam combined with nimodipine in cerebral infarction after vascular dementia. Methods 86 patients with vascular dementia were selected and randomly divided into control group and observation group,each group contained 43 cases. The patients in control group were treated with nimodipine,15 ~ 60 mg /count,2 counts / d; the patients in observation group were treated with piracetam in the basic of control group,0. 8 g / count,3 counts / d,both of the group were treated for 6 months. The curative effects,the scores of mini- mental state examination（ MMSE） and activities of daily living（ ADL） were compared between the two groups. Measurement data between groups was processed by t test,in group was processed by paired t test,count data was processed by chi square test,P 〈0. 05 was considered statistically significant. Results The total effective rate in the observation group（ 86. 04%） was significantly higher than that in control group（ 65. 11%）,the difference was statistically significant（ P 〈0. 05）. After treatment,the MMSE score in observation group and control group were（ 24. 84 ± 4. 38） and（ 20. 15 ± 3. 25） point,had significant improvement as compared with before treatment[（ 16. 37 ± 3. 05） and（ 16. 38 ± 3. 14） point]; the ADL score after treatment in observation group and control group were（ 23. 45 ± 9. 84） and（ 35. 15 ± 9. 72） point,had significant improvement as compared with before treatment[（ 38. 20 ± 9. 71） and（ 38. 15 ± 10. 04） ]point,the differences were statically significant（ all P 〈0. 05）. The MMSE score and ADL score in the observation group showing a better improvement than in control group,there were significant differences between the two groups（ all P 〈0. 05）. Conclusions The combination of piracetam and nimodipine for vascular dementia after cerebral infarction has an obvious effect,it also can increase the capacity of cognitive and worthy of clinical application.

关 键 词：血管性痴呆 脑梗死 吡拉西坦 尼莫地平 

分 类 号：R452[医药卫生—治疗学]