梗阻性黄疸对多器官系统损害及其机制的研究进展  

Research progress in mechanism of multiple organ injury in obstructive jaundice

作　　者：许朝龙 邬善敏[1] 

机构地区：[1]武汉大学人民医院肝胆腔镜外科,武汉430060

出　　处：《腹部外科》2015年第5期367-370,共4页Journal of Abdominal Surgery

摘　　要：梗阻性黄疸可引起多器官、多系统损伤,如引起肝脏损伤,破坏肠黏膜屏障,导致肾衰竭,降低心肌收缩力,引起急性肺损伤,影响胰腺内外分泌功能等.其损伤机制比较复杂,是内毒素血症、氧自由基、细胞因子、胆汁成分等各种因素所致损伤的综合作用.Jaundice can lead to multiple organ injury and multi-system damage, such as liver damage, intestinal barrier injury, renal failure, myocardial contractility decrease, acute lung injury, pancreatic endocrine and exocrine changes, etc. The mechanism of multiple organ injury in obstructive jaundice is complicated, which contains a variety of factors, like endotoxemia, oxygen free radicals, cytokines and bilirubin. In this article, we review the mechanism of multiple organ injury in obstructive jaundice.

关 键 词：梗阻性黄疸 脏器损伤 内毒素血症 

分 类 号：R657.43[医药卫生—外科学]