格列齐特对2型糖尿病GK大鼠离体心肌缺血预适应的影响  

Effect of gliclazide on ischemic preconditioning in isolated rat heart

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作  者:张中琳[1] 赵伟[1] 吴国亭[2] 

机构地区:[1]同济大学附属第十人民医院急诊科,上海200072 [2]同济大学附属第十人民医院内分泌科,上海200072

出  处:《同济大学学报(医学版)》2015年第5期39-42,共4页Journal of Tongji University(Medical Science)

基  金:上海市科委科技攻关基金重点资助项目(04DZ19507)

摘  要:目的研究格列齐特对糖尿病GK大鼠离体心脏缺血预适应(ischemic preconditioning,IPC)保护作用的影响。方法采用GK大鼠离体心脏Langendorff灌流模型,分为Wistar大鼠缺血预处理对照组(CON组)、GK大鼠缺血预适应保护组(GK组)、缺血预适应+格列齐特组(10μmol/L)(IPC+Glc组),每组8只。记录各组血流动力学指标,灌流后检测心肌梗死面积。结果灌流30 min时,与CON组相比,IPC+Glc组左心室功能有一定程度的改善(P<0.05),IPC+Glc组和GK组心肌梗死面积无明显变化(P>0.05)。结论格列齐特未影响缺血预适应对心肌的保护作用。Objective To investigate the effect of gliclazide on ischemic preconditioning( IPC) in isolated rat heart. Methods The hearts were isolated from male spontaneously diabetic g o to-kakiz aki( G K) rats and W istar rats. T he iso lated hearts were perf used with L ang endo rf f perf usio n sy stem, and rando m ly div ided into three g ro ups: W istar ischem ic preco nditio ning g ro up( co ntro l g ro up),G K ischem ic preco nditio ning g ro up( G K g ro up); G K ischem ic preco nditio ning + G liclaz ide( 1 0 μm m o l / L)( IPC + G lc g ro up),with 8 hearts in each g ro up. T he hem o dy nam ic index es were reco rded during the perf usio n and the inf arct siz e o f iso lated hearts was m easured af ter perf usio n. Results T he lef t v entricular f unctio n( d P / dt m ax and d P / dt m in) o f IPC + G lc g ro up was sig nif icantly im pro v ed at 3 0 m in af ter perf usio n co m pare with co ntro l g ro up( P〈0. 0 5). T here was no sig nif icant dif f erence in inf arct siz e between IPC + G lc g ro up and G K g ro up. Conclusion T he results sho wthat g liclaz ide do es no t af f ect the m y o cardial pro tectio n o f ischem ic preco nditio ning in G K rats.

关 键 词:格列齐特 心肌缺血预适应 langendorff灌流 GK大鼠 

分 类 号:R587.1[医药卫生—内分泌]

 

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