探讨联合检测血清缺血修饰白蛋白、超敏肌钙蛋白T水平对心肌缺血相关疾病的诊断价值  

Disussion on diagnostic value of combined detection serum ischemia modified albumin and high sensitivity troponin T level in myocardial ischemia related diseases

作　　者：陈传华[1] 马祥波[1] 罗艳华[1] 

机构地区：[1]广东省英德市人民医院检验科,广东英德513000

出　　处：《医学检验与临床》2015年第5期3-5,共3页Medical Laboratory Science and Clinics

基　　金：2014年度南通市市级科技计划项目（HS149058）

摘　　要：目的：研究血清缺血修饰白蛋白（1MA）及超敏肌钙蛋白T（hs-TnT）水平对心肌缺血引发相关疾病的临床诊断价值。方法：对我院2014年1月至2015年3月因胸痛、胸闷或急性心梗发作就诊患者150例，分别于入院2h、6h、12h、24h取样行1MA和hs-TnT检测，并根据出院诊断分组，观察各组患者不同时间段1MA和hs-TnT水平，通过回顾性分析研究1MA和hs-TnT在心肌缺血疾病诊断中的敏感性和特异性。结果：入院2h、6h，UA组、NSTEMI组、STEMI组IMA水平低于NICP组，组间比较差异明显（P＜0.05）；STEMI组IMA水平明显低于UA组、NSTEMI组（P＜0.05），入院6h、12h、24hUA组、NSTEMI组、STEMI组hs-TnT水平明显高于NICP组（P＜0.05）， NSTEMI组、STEMI组hs-TnT水平明显高于UA组（P＜0.05）。IMA单独诊断ACS的敏感性为70.6%，特异性为51.7%；IMA、hs-TnT联合诊断心肌缺血的敏感性和特异性分别为94.1%和72.9%，联合诊断敏感性和特异性均高于单独诊断（P＜0.05）。结论：联合检测IMA和hs-TnT对诊断心肌缺血引发的心血管疾病有较高的临床价值，同时两项指标联合应用可反映心肌缺血的发展进程，评估疾病严重程度，对指导治疗和预后的判断有一定作用。Objective：To study the clinical diagnostic value of serum ischemia modified albumin （1MA） and serum troponin T （hs-TnT） in the diagnosis of myocardial ischemia related diseases.Methods：In our hospital in January 2014 to 2015 March because of chest pain, chest tightness or acute myocardial infarction attack patients with 150 cases, respectively at admission for 2h, 6h, 12h, 24h sample 1mA and HS TNT detection and according to the discharge diagnosis group observed patients in each group at different time 1mA and HS TNT level, sensitivity and specificity in diagnosis of myocardial ischemia disease research 1mA and HS TNT were retrospectively analyzed.Results： Admission at 2h, 6h, UA, NSTEMI and STEMI group ima levels lower than group nicp, inter group significant differences （P〈 0.05）; IMA level in STEMI group was significantly lower than that of the UA and NSTEMI group （P〈 0.05）. Admission 6h, 12h, 24hUA, NSTEMI and STEMI group HS TNT level was significantly higher than that of nicp group （P〈 0.05）, NSTEMI and STEMI group HS TNT level was significantly higher than that of the UA group （P〈 0.05）. Ima alone, the diagnostic sensitivity of ACS was 70.6%, specificity was 51.7%; HS TNT and ima combined diagnosis sensitivity and specificity of myocardial ischemia were 94.1% and 72.9%, combined diagnostic sensitivity and specificity were higher than single diagnosis （P〈 0.05）.Conclusions：Clinical value of joint detection of IMA and HS TNT for the diagnosis of myocardial ischemia caused by cardiovascular diseases is high. At the same time, combined application of the two parameters can reflect the development of myocardial ischemia, to assess the severity of the disease, for the guidance of treatment and prognosis judgment have a role.

关 键 词：血清缺血修饰白蛋白 超敏肌钙蛋白T 心肌缺血 诊断价值 

分 类 号：R765.42[医药卫生—耳鼻咽喉科]