十三味和中丸治疗肝胃不和型功能性消化不良临床疗效观察及对患者生活质量的影响  

The clinical effect observation of Shisanweihezhongwan for functional dyspepsia of liver-stomach incoordination syndorome

作　　者：李学军[1] 江应露 张玉萍[2] 吴清林[2] 马骏[1] 金月萍[1] 陈亮亮[1] 

机构地区：[1]安徽中医药大学第二附属医院脾胃病科,安徽合肥230061 [2]安徽中医药大学,安徽合肥230038

出　　处：《中国中西医结合消化杂志》2015年第11期764-767,772,共5页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]观察十三味和中丸对肝胃不和型功能性消化不良(FD)患者临床症状及生活质量的改善作用。[方法]将48例肝胃不和型FD患者随机分为对照组和治疗组,每组各24例,分别采用西药多潘立酮与十三味和中丸进行治疗,疗程均为4周。观察并比较2组总体疗效及其治疗前后单项症状积分的变化情况;同时,采用SF-36健康调查量表评定2组患者治疗前后的生活质量。[结果]治疗组总有效率87.50%,显著高于对照组58.33%,并且在脘腹胀满、嗳气、胁肋窜痛和上腹部烧灼感等方面的改善程度明显优于对照组(P<0.05、P<0.01);同时,治疗组在生理职能、躯体疼痛、精神健康等维度的分数较治疗前改善明显(P<0.05、P<0.0 1),其中生理职能和精神健康等维度分数显著高于对照组(P<0.01)。[结论]十三味和中丸治疗肝胃不和型FD效果显著,可明显改善患者的生活质量。[Objective] To observe the therapeutic effects of Shisanweihezhongwan, a Chinese patent drug, in the improvement of the quality of life and clinical symptoms in functional dyspepsia （FD） patients with liver-stomach ineoordination syndorome. [Methods]A total of 48 FD patients of liver-stomach incoor- dination syndrome were averagely divided into matched group and treatment group randomly. The patients in the matched group were treated with domperidone,while the patients in the treatment group were trea- ted with Shisanweihezhongwan. The treatment course was 4 weeks in each group. The overall curative effect and the changes of individual symptom scores before and after treatment were observed and compared between the two groups. The SF-36 scale of health survey was used to assess the quality of life of all pa- tients before and after treatment. [Results]The overall clinical effectiveness rate was 87.50% in the treat- ment group,which was significantly higher than 58.33% in the matched group. The degrees of improve- ment in the treatment group were significantly higher than those in the matched group in abdominal full- ness and distension, epigastrie pain, belching, migratory pain in hypochondrium and burning sensation of epigastrium. After treatment,the score of dimension of role physical, bodily pain and mental health in the treatment group were significantly higher than those befor treatment,and the scores of physical role, soma- toform pain and mental health were significantly higher than those in the matched group. [Conclusion] Shisanweihezhongwan has obvious effects in treating FD of liver-stomach incoordination syndrome, and it can obviously improve patients＇ quality of life .

关 键 词：功能性消化不良 肝胃不和型 十三味和中丸 疗效 生活质量 

分 类 号：R256.3[医药卫生—中医内科学]