维生素D延缓慢性阻塞性肺疾病进展的有效性临床研究  

Clinical Study on Efficacy of Vitamin D on the Progression of Chronic Obstructive Pulmonary Disease

作　　者：顾文超[1] 齐广生[1] 袁亚平[1] 杨华[1] 吴浩[1] 唐志君[1] 王林宣 冯慧丽[1] 汪瑞忠[1] 

机构地区：[1]上海市浦东新区人民医院呼吸科,上海201299

出　　处：《中国医药导刊》2015年第11期1124-1125,共2页Chinese Journal of Medicinal Guide

基　　金：上海市卫生局(项目编号:20124489);课题名称:维生素D延缓慢性阻塞性肺疾病进展的有效性临床研究;上海浦东新区卫生系统领先人才培养计划(项目编号:PWR12014-04);课题名称:维生素D受体基因多态性与慢性阻塞性肺疾病的易感性研究

摘　　要：目的:探讨补充维生素D在减缓慢性阻塞性肺疾病(COPD)患者的肺功能减退,提高生活质量及运动耐量等方面的作用。方法:60例筛选合格的稳定期中重度COPD患者随机分成治疗组和对照组,各30例。治疗组给予口服液体钙+维生素D胶囊,对照组给予安慰剂。比较两组患者的各项指标。结果:治疗组肺功能FEV1、CAT,以及外周血中25(OH)D、INF-γ、IL-4以及INF-γ/IL-4较对照组均有意义的改变(P<0.05)。治疗组服用维生素D 1年后与其基数比较,可见FEV1、CAT,以及外周血中25(OH)D、INF-γ的改变具有统计学意义(P<0.05)。结论:稳定期COPD患者口服维生素D改善肺功能、生活质量,可能与改善Th1/Th2失衡有关。Objective： To investigate the effect of vitamin D supplementation on pulmonary function in patients with chronic obstructive pulmonary disease（COPD）, improve the quality of life and exercise tolerance. Methods： 60 patients with severe COPD were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was treated with liquid calcium ＋ vitamin D capsules, and the control group was treated with placebo. Compare two groups of patients with the indicators. Results： The treatment group, the lung function（FEV1, cat, and peripheral blood in 25（OH）D, INF-γ, IL-4 and INF-γ/IL-4 compared with the control group had significant changes（P〈0.05）. In treatment group were treated with vitamin D one year after its base comparison, visible FEV1, cat, and the changes in peripheral blood 25（OH）D, INF-γ is with statistical significance（P〈0.05）. Conclusion： Oral administration of stable COPD in patients with vitamin D improves lung function and quality of life, and may be related to the improvement of Th1/Th2 imbalance.

关 键 词：维生素D 稳定期慢性阻塞性肺疾病 临床疗效 

分 类 号：R563.9[医药卫生—呼吸系统]