替米沙坦对高血压前期患者血糖代谢的影响  

Effects of Telmisartan on the Glucose Metabolism Disorders in Patients with Prehypertension

作　　者：吕雅萍[1] 张军[2] 张爱华[1] 张杰[1] 王英海 段克东[1] 

机构地区：[1]河北省沧州市中心医院大化分院,沧州061001 [2]河北省沧州市中心医院心内五科,沧州061001

出　　处：《中国医药导刊》2015年第11期1141-1142,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:替米沙坦对高血压前期患者血糖代谢的影响。方法:选取180例高血压前期患者,随机分为两组,每组各90例,对照组患者给予硝苯地平控释片,观察组患者给予替米沙坦,观察并比较两组高血压前期患者的血糖变化。结果:在经过6月的治疗后,观察组与对照组患者的血压均有效降低,均具有统计学意义(P<0.05),同时观察组患者的空腹胰岛素(FINS)、2h胰岛素(2h INS)及稳态模型评估胰岛素抵抗指数(HOMA-IR)较治疗前降低,比较差异具有统计学意义(P<0.01),而对照组并无统计学意义(P>0.05)。结论:替米沙坦对高血压前期患者血糖代谢的改善作用明显。Objective： To investigate the effects of telmisartan on the glucose metabolism disorders in patients with prehypertension. Methods：180 cases of patients with prehypertension were divided into control group（90 cases） and observation group（90 cases）. observation group was given telmisartan and control group was given nifedipine. Blood pressure, FINS, 2h INS, HOMA-IR of two groups before and after treatment were observed and compared. Results：There were significant differences on systolic blood pressure（SBP）, diastolic blood pressure（DBP） between two groups after treatment（P〈0.05）.FINS, 2h INS, HOMA-IR of observation group after treatment were lower than that of before treatment（P〈0.01）. Conclusion：Telmisartan in the treatment of the glucose metabolism disorders in patients with prehypertension is safe and effective; it can improve the glucose metabolism disorder.

关 键 词：替米沙坦 高血压前期 血糖代谢 

分 类 号：R544.1[医药卫生—心血管疾病]