HMGR, SQS, β-AS, and Cytochrome P450 Monooxygenase Genes in Glycyrrhiza uralensis  

作　　者：Rui Yang Bo-chuan Yuan Yong-sheng Ma Li-qiang Wang Chun-sheng Liu Ying Liu 

机构地区：[1]School of Chinese Pharmacy, Beijing University of Chinese Medicine

出　　处：《Chinese Herbal Medicines》2015年第4期290-295,共6页中草药（英文版）

基　　金：Beijing Project for Young Talents(YETP0819);National Science Foundation of China(81503181)

摘　　要：Glycyrrhiza uralensis is frequently used in traditional Chinese medicine. This plant contains a large amount of effective constituents, including triterpenoids and flavonoids. Among them, glycyrrhizin is believed to be the marker compound to evaluate the quality of G. uralensis based on Chinese Pharmacopoeia. Many studies showed that glycyrrhizin possesses various pharmacological activities, such as antibacterial, antiviral, antitumor, anti-inflammatory, and immune-stimulating activities. In this paper, we summarized the cloning, characterization, expression, and polymorphism analysis of several functional genes involved in glycyrrhizin biosynthesis in G. uralensis.Glycyrrhiza uralensis is frequently used in traditional Chinese medicine. This plant contains a large amount of effective constituents, including triterpenoids and flavonoids. Among them, glycyrrhizin is believed to be the marker compound to evaluate the quality of G. uralensis based on Chinese Pharmacopoeia. Many studies showed that glycyrrhizin possesses various pharmacological activities, such as antibacterial, antiviral, antitumor, anti-inflammatory, and immune-stimulating activities. In this paper, we summarized the cloning, characterization, expression, and polymorphism analysis of several functional genes involved in glycyrrhizin biosynthesis in G. uralensis.

关 键 词：β-AS cytochrome P450 monooxygenase functional genes glycyrrhizin HMGR SQS 

分 类 号：R284[医药卫生—中药学]