Antipyretic Effects of Eupatorium chinense and Its Mechanism  

作　　者：Yi-ping Jiang Jiang-ping Xu 

机构地区：[1]Department of Neuropharmacology, School of Pharmaceutical Sciences, Southern Medical University

出　　处：《Chinese Herbal Medicines》2015年第4期323-327,共5页中草药（英文版）

摘　　要：Objective To investigate the antipyretic effect of Eupatorium chinense and its mechanism. Methods The content of arginine vasopressin（AVP） in ventral septal area（VSA） and blood plasma, and cyclic adenosine monophosphate（c AMP） levels of hypothalamus and blood plasma were determined by enzyme linked immunosorbent assay. Results The body temperature（Tb） was decreased at 1 h after administration of E. chinense（3 and 6 g/kg） and Aspirin（0.3 g/kg） respectively, which was significantly different from the temperature of fever model group. The antipyretic effect of Aspirin and E. chinense lasted for longer time. Aspirin（0.3 g/kg） and E. chinense（3 and 6 g/kg）reduced the level of cA MP in hypothalamus of fever rats and increased AVP content in plasma. The changes in c AMP content in plasma of all drug treatment groups were not obvious. Conclusion E. chinense has strong antipyretic effect and may affect the production of AVP and c AMP in fever rats.Objective To investigate the antipyretic effect of Eupatorium chinense and its mechanism. Methods The content of arginine vasopressin（AVP） in ventral septal area（VSA） and blood plasma, and cyclic adenosine monophosphate（c AMP） levels of hypothalamus and blood plasma were determined by enzyme linked immunosorbent assay. Results The body temperature（Tb） was decreased at 1 h after administration of E. chinense（3 and 6 g/kg） and Aspirin（0.3 g/kg） respectively, which was significantly different from the temperature of fever model group. The antipyretic effect of Aspirin and E. chinense lasted for longer time. Aspirin（0.3 g/kg） and E. chinense（3 and 6 g/kg）reduced the level of cA MP in hypothalamus of fever rats and increased AVP content in plasma. The changes in c AMP content in plasma of all drug treatment groups were not obvious. Conclusion E. chinense has strong antipyretic effect and may affect the production of AVP and c AMP in fever rats.

关 键 词：antipyretic arginine vasopressin cyclic adenosine monophosphate Eupatorium chinense ventral septal area 

分 类 号：R285.5[医药卫生—中药学]