蛇毒毒素的抗肿瘤作用及其在医药领域的应用  

The antitumor effect of snake venom toxins and its application in medical field

作　　者：金夕琳[1] 张洁[2] 江海龙[3] 陆一鸣[3] 

机构地区：[1]第二军医大学学员旅临床二队,上海200433 [2]国防大学第二门诊部,北京100039 [3]第二军医大学药学院生化药学教研室,上海200433

出　　处：《药学实践杂志》2015年第6期502-504,517,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金项目(No.81274162;30500093);国家科技部"重大新药创制"专项(No.2009ZX09103-690);上海市科委重点项目(No.04JC14002);军队"十一五"计划(No.06Q042);上海市高校优秀青年教师科研专项基金(No.ejd09011)

摘　　要：目的探讨蛇毒毒素的抗肿瘤作用及其在医药领域的应用。方法综述蛇毒毒素的抗肿瘤组分、抗肿瘤作用及其机制的研究进展。结果蛇毒毒素对多种肿瘤均有抑制作用,具有直接杀伤肿瘤细胞、诱导肿瘤细胞凋亡、抑制血管再生等作用。结论对蛇毒毒素抗肿瘤组分及其作用机制进行深入研究,是当前抗肿瘤药物研究的重要方向。Objective To discuss the antitumor effect of snake venom toxins and its application in medical field .Methods To review the research progress of composition ,the antitumor effect and mechanism of snake venom toxins .Results It was demonstrated that the snake venom toxins can stop various tumor cells from growing ,and have the functions of killing the tumor cells ,inducing cell death ,and inhibition of angiogenesis .Conclusion It is an important direction in antitumor drug re-search and development to deeply research the composition and the mechanisms of action of the snake venom toxins .

关 键 词：蛇毒毒素 抗肿瘤 

分 类 号：R931.74[医药卫生—生药学] R73[医药卫生—药学]