洛汀新与缬沙坦对老年急性心肌梗死患者心室重塑及心功能的影响  

Impact of Lotensin and Valsartan on Ventricular Remodeling and Cardiac Function of Elderly AMI Patients

作　　者：李广辉[1] 刘长缨[1] 彭昊帅 

机构地区：[1]河南省郑州人民医院药学部,河南郑州450000

出　　处：《中外医疗》2015年第19期132-133,共2页China & Foreign Medical Treatment

摘　　要：目的对洛汀新(盐酸贝那普利片)与缬沙坦治疗老年急性心肌梗死患者对心室重塑及心功能的影响进行探讨。方法回顾性分析从2013年1月—2014年12月期间的90例在该院接受治疗的心肌梗死老年患者的临床资料,并根据随机数字表法将患者分成观察组与对照组两组,各为45例。观察组使用洛汀新治疗,对照组使用缬沙坦治疗。对比两组临床治疗效果以及对患者心功能的影响。结果两组患者治疗后心室重塑指标改善明显,对比两组改善情况发现使用洛汀新治疗的观察组患者情况优于对照组,P<0.05;观察组患者治疗后心功能指标水平改善情况显著优于对照组,且差异有统计学意义,P<0.01;治疗后观察组临床症状评分与对照组比较明显降低,P<0.05;对照组NYHA分级显著低于观察组,P<0.05。结论对于老年急性心肌梗死患者采用洛汀新与缬沙坦治疗,可有效改善患者心功能,并帮助心室重建,临床具有推广意义。Objective To observe the impacts of Lotensin and Valsartan on ventricular remodeling and cardiac function of elderly AMI （acute myocardial infarction） patients. Methods The clinical data about 90 MI patients in our hospital from January 2013 to December 2014 was reviewed and the patients were randomly divided into observation group and control group, 45 cases each group. The observation group adopted Lotensin and control group adopted Valsartan. The clinical treatment effect and their impacts in the cardiac function of two groups were compared. Results After treatment, the ventricular remodeling index of two groups was greatly improved. the improvement of observation group was significantly better than that of control group （P〈0.05）; the improve-ment of cardiac function index of observation group was significantly better than that of control group （P〈0.01）;the clinical symp-tom score of observation group was significantly lower than that of control group （P〈0.05）;NYHA grading of control group was sig-nificantly lower than that of observation group （P〈0.05）.Conclusion For elderly AMI patients, Lotensin and Valsartan can effective-ly improve the cardiac function and remodel the ventricle. It is worthy of clinical promotion.

关 键 词：急性心肌梗死 心室重塑 新功能 洛汀新 缬沙坦 

分 类 号：R542.22[医药卫生—心血管疾病]