呼气相共振频率在小气道功能测定中的应用价值探讨  

Discussion of Application Value of Expiratory Phase Resonance Frequency in the Determination of Small Airway Function

作　　者：赵珊 王浩彦[2] 

机构地区：[1]北京房山区良乡医院呼吸科,北京102401 [2]首都医科大学附属北京友谊医院呼吸科,北京100050

出　　处：《中外医疗》2015年第14期177-180,共4页China & Foreign Medical Treatment

摘　　要：目的探讨呼气相共振频率(e Fres)在小气道功能测定中的应用价值。方法整群选取2012年1月—2013年1月于北京友谊医院及北京房山区良乡医院就诊的91例患者。同时采用肺通气功能法及脉冲振荡(IOS)进行测定,根据肺通气功能结果将患者分为小气道功能异常组与小气道功能正常组,将两组参数进行比较,分析e Fres与肺通气功能参数FEF25、FEF50、FEF75、MMEF的相关性,建立回归方程,并用受试者工作特征曲线(ROC曲线)研究e Fres诊断小气道功能异常的诊断准确性、灵敏度与特异度。结果小气道功能异常组参数Fres、e Fres、i Fres与小气道功能正常组相比,差异有统计学意义(P<0.001)。小气道功能异常组e Fres与FEF25、FEF50、FEF75、MMEF呈负相关(r=-0.467,r=-0.471,r=-0.435,r=-0.447,P<0.01)。回归方程显示,e Fres与小气道功能异常有回归关系。e Fres诊断小气道功能异常的曲线下面积为0.945[95%CI(0.898,0.991)],以e Fres>14.205作为小气道异常的分界点,诊断小气道功能异常的灵敏度、特异度分别为0.879,0.917。结论e Fres与肺通气功能参数FEF25、FEF 50、FEF75、MMEF均有很好的相关性,对小气道功能异常的诊断有较高准确性,对于不能配合进行肺通气功能检测的患者采用IOS法测定e Fres能够为小气道功能的评估提供参考。Objective Discussion of application value of expiratory phase resonance frequency （eFres）in the determination of small airway function. Methods 91 cases of hospital patients＆#39; selection from Beijing Friendship Hospital and Beijing Fangshan District Liang Xiang Hospital during the time from January 2012 to January 2013, and measured by pulmonary ventilation func-tion and impulse oscillometry （IOS）. Dividing patients into the small airway function abnormal group and the small airway func-tion normal group according to the results of pulmonary ventilation function, comparing the two sets of parameters, analyzing the correlation of eFres and the pulmonary ventilation function parameters, FEF25、FEF 50、FEF75、MMEF, establishing the regression curve equation, and researching the accuracy, sensitivity and specificity of eFres in the diagnosis of small airway function abnor-mality by using receiver operating characteristic curves （ROC）. Results Comparing parameters, Fres、eFres、iFres of the small air-way function abnormal group and the small airway function normal group, the difference is statistically significant （P〈0.001）. In the small airway function abnormal group, there is a negative correlation between eFres and FEF25、FEF 0、FEF75、MMEF （r=-0.467,r=-0.471,r=-0.435,r=-0.447,P〈0.01）. The regression equation shows that eFres has regression relationship with abnormal function of small airway. Area under the curve（AUC） of the eFres diagnosis of small airway function is 0.945[95%CI（0.898,0.991）], use eFres〉14.205 as the cut-off point of small airway＆#39;s abnormality, the sensitivity and specificity degrees of small airway function are 0.879 and 0.917. Conclusion There is a good correlations between eFres and pulmonary ventilation function parameters, FEF25、FEF 50、FEF75、MMEF. The eFres has a high accuracy to the diagnosis of small airway function. For the patients unable to cooperate with taking pulmonary ventilation function test, IOS method can be used, and eFre

关 键 词：呼气相共振频率 脉冲振荡法 小气道功能 

分 类 号：R4[医药卫生—临床医学]