内皮钙粘蛋白及内皮素-1与2型糖尿病大血管病变关系  

The relationship between serum VE-cadherin and endothelin and type 2 diabetic mellitus macrovasicular complication

作　　者：谭子新[1] 王秀丽[1] 秦冰 白银涛 杨慧[1] 孙亚威[1] 

机构地区：[1]邯郸市第一医院,河北邯郸056002 [2]邯郸市口腔医院,河北邯郸056001

出　　处：《中国热带医学》2015年第11期1399-1401,共3页China Tropical Medicine

摘　　要：目的探讨血清血管内皮钙粘蛋白(VE-Ca)及内皮素-1(ET-1)与2型糖尿病合并大血管病变的关系。方法将104例2型糖尿病患者分为大血管病变组(MCV,58例),无大血管病变组(Non-MCV,46例),并选取37例健康者作为对照组。记录年龄,测量收缩压、舒张压,检测各项血脂指标、空腹血糖、糖化血红蛋白。用ELISA法测定VE-Ca和ET-1的水平。结果 MCV组VE-Ca和ET-1的水平高于Non-MCV、对照组(NC组)(P<0.05或P<0.01),Non-MCV组高于NC组(P<0.05或P<0.01);血清VE-Ca与ET-1、SBP、DBP、FPG、TG、Hb A1c正相关(r=0.284,0.367,0.380,0.737,0.322,0.745,P<0.01或P<0.05),与HDL负相关(r=-0.208,P<0.05);Logistic回归分析显示,VE-Ca、ET-1、DBP、TG与T2DM合并MCV独立相关。结论血清VE-Ca及ET-1的水平与MCV相关,VE-Ca与ET-1在MCV发生发展过程中可能起重要作用。Objective To study the relationship of serum VE- cadherin（VE- Ca）and Endothelin 1（ET- 1）with thepathogenesis of macroangiopathy in type 2 diabetes mellitus（T2DM）patients. Methods A total of 104 T2 DM patients weredivided into macrovascular complications group（MCV,n=58）and non-macrovascular complications group（non-MCV,n=46）,and 37 healthy individuals were selected as the control group（NC）. Age,SBP,DBP,TC,TG,HDL,LDL,FPG and Hb A1 cof the subjects were measured and levels of serum VE-Ca and ET-1 were detected by enzyme-linked immunosorbent assay.Results Levels of serum VE-Ca and ET-1 of patients in MCV group were significantly higher than those in Non-MCV andNC groups（P〈0.05or0.01）. VE-Ca and ET-1 levels were higher in patients of Non-MCV group than those in NC group（P〈0.05or0.01）. The serum VE-Ca was positively correlated with ET-1,SBP,DBP,FPG,TG and Hb A1 c levels（r=0.284,0.367,0.380,0.737,0.745,P〈0.05 or P〈0.01）and negatively correlated with HDL（r=-0.208,P〈0.05）.Logistic regression analysisshowed that VE- Ca,ET- 1,DBP and TG were significantly associated with the development of T2 DM macroangiopathyindependently.Conclusion Levels of serum VE- Ca and ET- 1 are associated with initiation and progression of T2 DMmacroangiopathy.The VE-Ca and ET-1 may play an important role in the pathological course of atherosclerosis.

关 键 词：血管内皮钙粘蛋白 内皮素-1 2型糖尿病 大血管病变 

分 类 号：R587.1[医药卫生—内分泌]