良恶性卵巢甲状腺肿组织中CK19、Galectin-3、CD56蛋白的表达及鉴别诊断价值  

Value of CK19,Galectin-3,and CD56 in the differential diagnosis about benign and malignant struma ovarii

作　　者：邵世清[1] 杨少琴[1] 黄贵[2] 田君[1] 张红霞[1] 王社莲[1] 

机构地区：[1]河南大学淮河医院妇产科,开封475000 [2]河南大学淮河医院病理科,开封475000

出　　处：《郑州大学学报（医学版）》2015年第6期847-850,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨CK19、Galectin-3及CD56在良恶性卵巢甲状腺肿鉴别诊断中的应用价值。方法:采用免疫组化法检测6例卵巢甲状腺癌和10例卵巢甲状腺肿组织中CK19、Galectin-3及CD56蛋白表达情况。结果:卵巢甲状腺癌组织中CK19、Galectin-3蛋白的表达高于卵巢甲状腺肿组织(t=4.807,3.835,P均<0.05),CD56蛋白的表达低于卵巢甲状腺肿组织(t=3.105,P均<0.05)。分别利用CK19、Galectin-3及CD56蛋白表达水平绘制ROC曲线,曲线下面积(AUC)分别为0.983、0.933和0.867;以其中1个指标恶性即判定为恶性,则3者联合检测对良恶性卵巢甲状腺肿鉴别诊断的灵敏度可达100%。结论:CK19、Galectin-3及CD56对卵巢甲状腺肿良恶性的鉴别有很好的应用价值。Value of CK19,Galectin-3,and CD56 in the differential diagnosis about benign and malignant strumaAim：To explore the value of CK19,Galectin-3 and CD56 in differential diagnosis about benign and malig-nant struma ovarii.Methods：The expressions of CK19,Galectin-3,and CD56 protein in 6 cases of thyroid carcinoma of ovary and 10 cases of ovarian goiter tissue were detected using immunohistochemical staining technique .Results： Compared with those of the ovarian goiter tissue , the expressions of CK19 and Galectin-3 were higher and CD56 protein expression was lower in thyroid carcinoma of ovary tissue （t=4.807,3.835,3.105,P〈0.05）.The AUC of ROC about CK19,Galectin-3,and CD56 protein was 0.983,0.933 and 0.867,respectively, and sensitivity of the joint detection with the 3 proteins was 100%.Con-clusion：CK19,Galectin-3 and CD56 may be used as diagnostic indicators of benign and malignant struma ovarii .

关 键 词：卵巢甲状腺肿 CK19 GALECTIN-3 CD56 

分 类 号：R711[医药卫生—妇产科学]