Study on Coagulation Activity of Callicarpa nudiflora  

裸花紫珠凝血活性研究（英文）

作　　者：杨子明 黄胜 颜小捷 张利 谷陟欣 李典鹏 

机构地区：[1]广西植物功能物质研究与利用重点实验室/广西植物研究所,广西桂林541006 [2]九芝堂股份有限公司,湖南长沙410008 [3]海南九芝堂药业有限公司,海南海口570311

出　　处：《Agricultural Science & Technology》2015年第11期2509-2512,共4页农业科学与技术（英文版）

基　　金：Supported by National Key Technology Research and Development Program(SQ2010BAJY1411-07-05);Special Fund for Modernization of Traditional Chinese Medicine in Hainan Province(2015ZY20);Major Science and Technology Project of Hainan Province(ZDZX2013008-01-04);Director Fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization(ZRJJ2014-7,ZRJJ2015-14);Bagui Scholar Program of Guangxi~~

摘　　要：[Objective] This study aimed to study the coagulation effect of Callicarpa nudiflora. [Method] The effects of CaUtcarpa nudiflora on blood coagulation system of mice were investigated by measuring prothmmbin time （PT）, thrombin time（TT）, activated partial thromboplastin time （APTT） and plasma fibrinogen （FIB）, [Result] Compared with the control group, the crude extracts and ：eluted parts of Ca#/carpa nudiflora all significantly shortened PT, APTT and TT, and increased the content of FIB in mice, [Coadadon] The crude extracts and eluted parts of Callicarpa nudiflora have a coagulation-promoting effect through affecting several links of the coagulation process in mice,[目的]研究裸花紫珠凝血作用。[方法]以小鼠为研究对象,通过测定其凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)4项指标观察裸花紫珠对试验动物凝血系统的影响。[结果]与空白对照组比较,裸花紫珠粗提物组及备洗脱部位组均能能明显缩短PT、APTT、TT的时间,能明显提高FIB含量。[结论]裸花紫珠及备洗脱部位可以通过影响实验动物凝血系统的多个环节发挥其凝血作用。

关 键 词：Callicarpa nudiflora COAGULATION MICE Prothrombin time 

分 类 号：S853.7[农业科学—临床兽医学]