香术茯苓颗粒的镇痛和抗菌作用  

Analgesic and antibacteria effects of Ageratum rhizoma Atractylodis Tuckahoe granules

作　　者：王宇翎[1] 吴文宁[1] 林杰[1] 杨梦媛[1] 朱韬[1] 罗欢[1] 

机构地区：[1]安徽医科大学基础医学院药理学教研室,合肥230032

出　　处：《安徽医科大学学报》2015年第12期1770-1772,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽高等学校省级自然科学研究项目(编号:KJ2013A146)

摘　　要：目的通过观察香术茯苓颗粒的镇痛和抗菌作用,探讨其治疗腹泻的可能机制。方法通过小鼠热板法和扭体法,观察香术茯苓颗粒的镇痛作用。采用血清药理学和体外抗菌试验,观察香术茯苓颗粒的抗菌作用。结果香术茯苓颗粒3、6 g/kg给药3 d可延长小鼠疼痛潜伏期,减少冰醋酸引起的小鼠扭体次数,具有显著的镇痛作用;血清药理学实验显示,香术茯苓颗粒6 g/kg给药3 d血清可以增加大肠埃希菌抑菌圈直径,有明显的抑菌作用;但对伤寒杆菌和金黄色葡萄球菌无作用。体外抗菌实验显示,香术茯苓颗粒对大肠埃希菌的最低抑菌浓度(MIC)为20.0 mg/ml,最低杀菌浓度(MBC)为80.0 mg/ml;对伤寒杆菌和金黄色葡萄球菌的MIC均为160.0 mg/ml,未测出MBC值。结论香术茯苓颗粒具有一定的镇痛和抗菌作用,可能是其治疗腹泻的部分机制。Objective To study analgesic and antibactcria effects of Ageratum rhizoma Atractylodis Tuckahoe gran- ules （ARTG）. Methods Hot-plate test and writhing test were used to study the analgesic effects of ARTG . Serum pharmacology and the antibacterial activity in vitro were used to study antibacteria effects of ARTG. Results ARTG（3,6 g/kg）administrated three days could increase the pain threshold in mice, decrease twist times induced by acetic acid. The serum pharmacology showed the serum of three days by ARTG（6 g/kg）had significally bacteri- ostatic effects against Escherichia coll. , but no effect on Typhoid bacillus and Staphylococcus aureus. In vitro, ARTG had certain bacteriostatic and bactericidal effects against Escherichia coli., but no bactericidal effects against Typhoid bacillus and Staphylococcus aureus. Conclusion ARTG has analgesic and antibacteria effects in animal models, and they might be the part mechanism in treating diarrhea.

关 键 词：香术茯苓颗粒 抗菌作用 镇痛作用 

分 类 号：R965.2[医药卫生—药理学]