川崎病患儿血清IL-9检测的临床意义  

Clinical Significance of Serum Interleukin-9 Detection in Children with Kawasaki Disease

作　　者：罗景华[1] 李国林[1] 宋小华[1] 曹晓春[1] 叶春风[1] 

机构地区：[1]南昌大学第二附属医院儿科,南昌330006

出　　处：《南昌大学学报（医学版）》2015年第5期45-47,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨川崎病(Kawasaki disease,KD)患儿血清IL-9水平的变化及其临床意义。方法收集KD患儿42例(KD组),其中包含10例冠状动脉损害(coronary artery lesion,CAL)患儿;另选健康体检儿童32例作为对照。采用双抗体夹心酶联免疫吸附法检测KD患儿急性期、缓解期及对照组血清中IL-9和IgE水平,同时检测血清C反应蛋白(CRP)水平。结果 KD急性期患儿血清IL-9、CRP、IgE水平明显高于缓解期KD患儿及对照组(均P<0.05);缓解期KD患儿与对照组相比,差异无统计学意义(P>0.05)。KD急性期患儿血清IL-9水平与CRP、IgE水平呈正相关(r=0.725、0.750,均P<0.01)。KD伴有CAL患儿IL-9水平与不伴有CAL患儿相比,差异无统计学意义(P>0.05)。结论 IL-9可能参与了KD的早期发病过程,与疾病活动性有关。Objective To explore the serum level of interleukin-9（IL-9）and its clinical signifi-cance in children with Kawasaki disease（KD）.Methods Serum levels of IL-9,IgE and C-reactive were detected by enzyme-linked immunosorbent assay in 42 children with KD,including 10 chil-dren with coronary artery lesion（CAL）.In addition,32 healthy children were selected as the con-trols.Results Serum levels of IL-9,CRP and IgE in children with KD in acute phase were signifi-cantly higher than those in children with KD in remission phase and healthy controls（P 〈0.05）. There no significant differences in these indexes between children with KD in remission phase and healthy controls（P〉0.05）.The levels of IL-9 were positively correlated with CRP and IgE levels in children with KD in acute phase（r =0.725 and 0.750,respectively;P 〈0.01）.No significant differences in the levels of IL-9 were found between children with CAL and children without CAL （P 〉0.05）.Conclusion IL-9 may be involved in the early pathogenesis of KD,which is associated with the activity of disease.

关 键 词：川崎病 白细胞介素-9 儿童 

分 类 号：R725[医药卫生—儿科]