晚期结直肠癌的化疗进展  

Advances in chemotherapy for advanced colorectal cancer

作　　者：李文桦[1] 张文[1] 

机构地区：[1]复旦大学附属肿瘤医院肿瘤内科,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国癌症杂志》2015年第11期877-889,共13页China Oncology

摘　　要：化疗是晚期结直肠癌的主要治疗手段,以氟尿嘧啶(5-fluorouracil,5-FU)、奥沙利铂和伊立替康为主的三药是晚期肠癌治疗的重要药物,联合化疗和"打打停停"的治疗模式在提高疗效的同时兼顾了治疗的耐受性。新的化疗药物雷替曲塞、替吉奥和TAS-102也在临床中获得应用。就晚期结直肠癌化疗的进展进行综述。Chemotherapy is the main treatment approach for advanced colorectal cancer. The 5-fluorouracil （5-FU）, oxaliplatin and irinotecan are three major chemotherapeutic drugs. The combined chemotherapy and ＂stop and go＂ treatment mode increase the efficacy and patients＇ tolerance. The new drugs, raltitrexed, S-1 and TAS-102, have been approved for use in cancer treatment. This article reviews the new development in chemotherapy tbr the treatment of advanced colorectal cancer.

关 键 词：结直肠癌 化疗 转移 

分 类 号：R735.3[医药卫生—肿瘤]