不同浓度丝裂霉素C对Ⅱ-Ⅲ型鼻窦炎术后疗效的影响  

Clinical estimation of different concentration of mytomycin C in treating in patients with Ⅱ-Ⅲ styles chronic suppurative sinusitis

作　　者：高永平[1] 刘会清[1] 马金莹[1] 冉程[1] 杜锦朵[1] 

机构地区：[1]河北大学附属医院耳鼻喉科,河北保定071000

出　　处：《医学研究与教育》2015年第5期26-28,共3页Medical Research and Education

摘　　要：目的 通过观察在Ⅱ-Ⅲ型鼻窦炎患者手术中应用不同浓度丝裂霉素C后鼻腔粘连情况,从而寻找一种安全有效的丝裂霉素C应用方案。方法 选择慢性鼻窦炎Ⅱ-Ⅲ型患者随机分成A组、B组行鼻内镜手术420例。A组应用0.2 g/L丝裂霉素C 210例,B组应用0.4 g/L丝裂霉素C 210例。术后定期随访18-30个月,平均（20.5±1.02）个月。结果 A组治愈186例,治愈率为88.6%,鼻腔粘连24例,无效率为11.4%;B组治愈202例,治愈率为96.2%,鼻腔粘连8例,无效率3.8%。2组治愈率差异有统计学意义。结论 鼻腔手术中局部应用0.4 g/L丝裂霉素C能明显减少术后鼻腔粘连,提高手术疗效。Objective To assess the efficacy of different concentration mitomycin C （MMC） in treating patients with II-III styles chronic suppurative sinusitis to find out an effective method for using MMC. Methods 420 cases with II-III styles chronic suppurative sinusitis were randomized to group A and group B. The patients in group A were used 0.2 g/L MMC in operation, group B used 0.4 g/L MMC in operation. All patients had follow-up study with the time of 18-30 months（20.5- 1.02 months） postoperatively. Results In group A,186 cases were cured,the cure rate was 88.6%, nasal cavity adhesion were 24 cases,invalid rate was 11.4%. In group B, 202 cases were cured,the cure rate was 96.2%, nasal cavity adhesion were 8 cases, invalid rate was 3.8%. Conclusion lntraoperative MMC seems to be a safe and effective procedure and can decrease nasal cavity adhesion.

关 键 词：丝裂霉素C 鼻腔粘连 慢性鼻窦炎 

分 类 号：R765[医药卫生—耳鼻咽喉科]