检测尿中巯基筛诊宫颈癌与癌前病变的临床意义  

Clinical Significance of Detection of Sulfhydryl in Urine for Screening Cervical Precancerous Lesion and Cancer

作　　者：刘爽[1] 

机构地区：[1]济南市第五人民医院妇科,山东济南250022

出　　处：《中外医疗》2015年第20期1-3,共3页China & Foreign Medical Treatment

摘　　要：目的研究检测尿中巯基筛诊宫颈癌与癌前病变的临床意义。方法按照随机分号法将在该院2014年1—12月间就诊及体检的90例宫颈疾病患者均分为3组,对观察组30例患者进行尿中巯基检测,对对照一组30例患者进行宫颈液基细胞学(TCT)检查或者对照二组30例患者进行高危型人乳头瘤病毒检查(HPV),对比观察3组的筛查意义。结果与最终病理学检查结果相比,观察组患者的宫颈癌与癌前病变检出率基本一致,且检出灵敏度基本一致,差异无统计学意义(P>0.05);对照一组与对照二组的宫颈癌与癌前病变检出率均差异较大,且检出灵敏度均显著低于病理检查结果 ,差异有统计学意义(P<0.05);在患者满意度方面,观察组患者为96.67%,对照一组患者为83.33%,对照二组患者为80.00%,观察组明显更具优势,差异有统计学意义(P<0.05)。结论相对于宫颈液基细胞学检测和高危型人乳头瘤病毒检查,采用尿中巯基筛查宫颈癌和癌前病变的临床价值较大,其可以明显提高检出率与检出灵敏度,改善患者满意度,值得临床推广使用。Objective To study the clinical significance of detection of sulfhydryl in urine for screening cervical precancerous lesion and cancer. Methods 90 cases with cervical disease visited our hospital and underwent physical examination from January2014 to December 2014 were divided into three groups, the observation group, control group 1 and control group 2 with 30 cases in each in accordance with the stochastic method. The observation group underwent the testing of sulfhydryl in urine, control group1 underwent cervical liquid based cytology（TCT）, and control group 2 underwent high-risk human papilloma virus（HPV） test. And the significance of detection was compared between the three groups. Results The detection rate of cervical precancerous lesion and cancer and detection sensitivity in the observation group were basically corresponded to the final pathology results with no statistically significant difference（P〉0.05）. Compared with the final pathology results, the detection sensitivity was much lower in control group 1 and control group 2, and there was statistically significant difference in the detection rate of cervical precancerous lesion and cancer of control group 1 and control group 2 with that of final pathology results（P〈0.05）; the level of patient satisfaction was 96.67% in the observation group, 83.33% in control group1, and 80.00% in control group 2, the observation group had much higher level of patient satisfaction（P〈0.05）. Conclusion Compared with TCT and high-risk HPV test, the clinical value of testing of sulfhydryl in urine for screening cervical precancerous lesion and cancer is greater, which can significantly improve the detection rate and sensitivity, increase the level of patient satisfaction, so it is worthy of clinical promotion and application.Department of Gynecology, The 5th People＇s Hospital of Jinan, Jinan, Shandong Province, 250022 China

关 键 词：宫颈液基细胞学 高危型人乳头瘤病毒检查 宫颈癌 癌前病变 检出灵敏度 

分 类 号：R5[医药卫生—内科学]