醋酸钙片对血液透析高磷血症患者血Ca、P水平的影响分析  

Analysis of the influence of Ca、P levels of calcium acetate tablets on hemodialysis patients with hyperphosphatemia

作　　者：朱再志 白佳柠 袁锦[1] 邹茜婷[1] 晁群[1] 许志忠[1] 

机构地区：[1]眉山市人民医院肾病内科,四川620010

出　　处：《国际泌尿系统杂志》2015年第6期871-873,共3页International Journal of Urology and Nephrology

摘　　要：目的 探讨醋酸钙片对血液透析（HD）高磷血症患者血钙（Ca）、磷（P）水平的影响.方法 选择2012年2月至2014年2月本院收治的HD高磷血症患者64例,随机分为研究组（32例）和对照组（32例）.在原有HD方案的基础上,对照组患者采用碳酸钙片治疗,研究组患者采用醋酸钙片治疗.结果 研究组治疗4周、治疗8周时P及CaP乘积显著降低,与治疗前相比差异具有统计学意义（P＜0.05）;且治疗8周时P及CaP乘积显著低于对照组（P＜0.05）.两组Ca、iPTH水平对比差异无统计学意义（P＞0.05）.研究组药物不良反应发生率为18.75％,对照组为21.86％,两组患者不良反应症状均较轻微,减药或停药后症状完全消失.结论 醋酸钙片可以有效控制HD高磷血症患者体内的P水平,且对Ca无明显影响,大大降低了高钙血症的发生机率,疗效确切,安全性佳,适于临床推广与应用。Objectives To investigate influence of Ca,P levels of Calcium Acetate Tablets on hemodialysis patients with hyperphosphatemia.Methods Selected 64 HD patients with hyperphosphatemia in 2012 February ～2014 February in our hospital,which were randomly divided into the study group（32 cases） and control group （32 cases）.On the basis of the original HD scheme,the control group was treated with Calcium Carbonate Tablets treatment,the study group was trcated with Calcium Acetate Tablets treatment.Results For 4 weeks,8 weeks of treatment,P and CaP product in the study group were significantly reduced than before treatment,the difference was statistically significant （P 〈0.05）;and the 8 weeks of treatment P and CaP product was significantly lower than the control group（P 〈 0.05）.The two groups had no statistically significant difference between Ca,iPTH levels （P 〉0.05）.The incidence of adverse reaction of study group was 18.75%,the incidence of adverse reaction of control group 28.13%,two groups of patients with adverse reactions were mild.Conclusions Calcium Acetate Tablets can effectively control HD hyperphosphatemia in patients with the level of P in vivo,and had no significant effect on Ca,reduced the incidence of hypercalcemia,efficacy,safety,and it is suitable for clinical popularization and application.

关 键 词：肾透析 高磷血症 钙 磷 

分 类 号：R459.52[医药卫生—治疗学]