顶空毛细管气相色谱法测定^18F-氟代乙酸盐中有机溶剂残留  

Determination of residual organic solvents in ^18F-FAC by gas chromatography

作　　者：郭莘[1] 戴红峰[1] 周硕[1] 陈文新[1] 

机构地区：[1]福建省立医院核医学科PET/CT中心,福州350001

出　　处：《国际放射医学核医学杂志》2015年第6期458-461,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：基金项目：福建省卫生系统中青年骨干人才培养项目（2013-ZQN-JC-4）

摘　　要：目的建立以毛细管气相色谱法测定^18F-氟代乙酸盐（^18F-FAC）中乙腈、丙酮和乙醇3种有机溶剂残留量的方法。方法采用HP-INNOWAX（30m×0．53mm，1μm）毛细管色谱柱和氢火焰离子化检测器，检测器温度为270℃，进样口温度为200℃，柱温采用程序升温，载气为氮气，进样量为1μl。结果乙腈、丙酮和乙醇均能得到较好的分离，呈现良好的线性关系，相关系数分别为：0．9999、0．9973、0．9988，平均回收率分别为99．8％、101．0％、97．5％，相对标准偏差值分别为4．6％、4．0％、1．5％。结论毛细管气相色谱法简便快速、灵敏度高、结果准确可靠，适用于^18F—FAC中残留有机溶剂的测定。Objective To develop a method for residual organic solvent determination in ^18F- fluoroacetate （ISF-FAC） using capillary gas chromatography. Methods The residual organic solvents were separated on the HP-INNOWAX capillary chromatographic column using temperature programming. Nitrogen gas was used as the carrier gas, along with a flame ionization detector （FID）. The FID and injector temperatures were 270℃ and 200℃, respectively, and the injection volume was 1μl. Results Good linear relationships in the experimental concentrations （r=0.9999, 0.9973, 0.9988） were observed. The three residual organic solvents were separated completely; the average recoveries were 99.8%, 101.0%, and 97.5%, and the relative standard deviation values were 4.6%, 4.0%, and 1.5%, respectively. Conclusion The proposed method is simple, rapid, accurate, and highly sensitive, which can be used in detecting residual organic solvents in ISF-FAC.

关 键 词：氟醋酸盐类 色谱法 气相 有机溶剂残留量 

分 类 号：R927[医药卫生—药学] O657[理学—分析化学]