电离辐射诱发动脉粥样硬化的研究进展  

Research progress of radiation induced atherosclerosis

作　　者：肖林林[1,2] 金问森[2] 张江虹[1] 邵春林[1] 

机构地区：[1]复旦大学放射医学研究所放射生物研究部,上海200032 [2]安徽医科大学核医学教研室,合肥230001

出　　处：《国际放射医学核医学杂志》2015年第6期493-496,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：基金项目：国家自然科学基金（81273001,11179002,31200631）;教育部高等学校博士学科点专项科研基金（20120071110057）

摘　　要：电离辐射可以诱发动脉粥样硬化（AS）。随着接受辐射治疗后长期存活肿瘤患者的增多，受照射人群心血管疾病的发病率也明显增加。辐射诱发AS涉及炎症性改变、氧化应激及基因不稳定性等过程，电离辐射旁效应也可能与AS的发病存在一定相关性。笔者对近年来辐射诱发AS的相关研究进行了概述，试图为深入研究辐射诱导AS的形成机制、为放射治疗预防药物靶点的选择提供一定的思路。Ionizing radiation can induce atherosclerosis（AS）. With increasing survival of patients after radiation therapy, the incidence of cardiovascular disease has increased significantly in the irradiated population. It is important to know the pathogenesis of ionizing radiation-induced AS. Amount of studies showed that the occurrence of AS is related to radiation-induced inflammatory, oxidative stress and genomic instability. Radiation induced bystander effect might also plays an effective role in AS induction. We hereby reviewed recent reports about radiation-induced AS and try to increase the knowledge of targeting therapy.

关 键 词：辐射 电离 动脉粥样硬化 辐射旁效应 

分 类 号：R818[医药卫生—放射医学]