布比卡因与罗哌卡因在老年下腹部及下肢手术患者腰-硬联合麻醉中的应用效果对比  

Effect comparsion of bupivacaine and ropivacaine in combined spinal epidural anesthesia for elderly patients undergoing lower abdomen or lower limb surgery

作　　者：付颖[1] 刘丹[1] 陈婷婷[1] 王晓娇[1] 

机构地区：[1]四川省眉山市人民医院麻醉科,620010

出　　处：《临床合理用药杂志》2015年第33期74-75,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的比较布比卡因、罗哌卡因腰-硬联合麻醉用于老年患者下腹部及下肢手术的效果。方法选取2013年5月—2015年5月在眉山市人民医院行择期下腹部及下肢手术的老年患者72例,分为布比卡因组(37例)和罗哌卡因组(35例),比较两组血流动力学变化情况及麻醉效果。结果麻醉前两组患者平均动脉压(MAP)、心率(HR)及血氧饱和度(SpO_2)比较,差异无统计学意义(P>0.05),给药5min后布比卡因组MAP、HR低于罗哌卡因组,差异有统计学意义(P<0.05)。布比卡因组出现最高阻滞平面时间短于罗哌卡因组,不良反应发生率高于罗哌卡因组,差异有统计学意义(P<0.05)。结论罗哌卡因用于老年患者下腹部及下肢手术腰-硬联合麻醉,在维持麻醉后血流动力学稳定、降低不良反应发生率方面均较布比卡因有一定的优势。Objective To compare the effect of bupivacaine and ropivacaine in combined spinal epidural anesthesia for elderly patients with undergoing lower abdominal or lower limb surgery. Methods A total of 72 cases of elderly patients un-dergoing abdominal or lower limb surgery were selected in the People＇s Hospital Meishan City from May 2013 to May 2015,they were divided into bupivacaine group（37 cases）and ropivacaine group（35 cases）,the hemodynamic changes and anesthesia effect between the two groups were compared. Results The mean arterial pressure（MAP）,heart rate（HR）and oxygen sat-uration（SpO2 ）between the two groups before anesthesia were compared,the differences were not statistically significant（P 〉0. 05）;MP and HR of bupivacaine group after 5min of injecting drug were lower than ropivacaine group,the differences were statistically significant（P 〈 0. 05）. The block time of reached the highest level of bupivacaine group was faster than ropivacaine group（P 〈 0. 05）,the incidence of adverse reactions was higher than ropivacaine group（P 〈 0. 05）. Conclusion Using rop-ivacaine in elderly patients undergoing lower abdominal and lower limb surgery combined spinal epidural anesthesia,compared with bupivacaine,it has certain advantages in maintain anesthesia hemodynamic stability,reduce the incidence of adverse reac-tions and complications.

关 键 词：麻醉 硬膜外 老年人 布比卡因 罗哌卡因 外科手术 

分 类 号：R614[医药卫生—麻醉学]