上海农村社区老年人高同型半胱氨酸血症患病率及其相关因素  

The prevalence and risk factors of hyperhomocysteinemia in elderly people in a rural community of Shanghai

作　　者：邓秋琼[1] 高黎黎 付建辉[3,4] 潘丹红 肖伟忠 李清华 丁玎[4] 潘雪君 余波 

机构地区：[1]上海市静安区中心医院神经内科,上海200040 [2]上海市浦东医院科创中心,上海201300 [3]上海市浦东医院神经内科,上海201300 [4]复旦大学附属华山医院神经内科,上海200040 [5]上海市浦东新区大团社区卫生中心,上海201300 [6]上海市浦东医院血管外科,上海201300

出　　处：《复旦学报（医学版）》2015年第6期722-726,共5页Fudan University Journal of Medical Sciences

基　　金：上海市浦东新区卫计委联合攻关项目(PW2013D-13)~~

摘　　要：目的研究上海市农村社区老年人群高同型半胱氨酸血症（hyperhomocysteinemia,HHcy）的患病率和分布特征,并分析其主要相关因素。方法以上海市浦东新区大团社区≥60岁老年人群为研究对象,通过横断面调查检测其血浆同型半胱氨酸（homocysteine,Hcy）水平及分布特征,并采用多因素非条件Logistic回归分析影响Hcy水平的高危因素。结果在1 621例≥60岁的老年人群中,男性血浆Hcy平均水平高于女性[（15.72±9.22）μmol/L vs.（14.08±7.55）μmol/L,P〈0.001],男性HHcy患病率高于女性（43.6%vs.29.5%,P〈0.001）。〈70岁、70-80岁、〉80岁的老年人血浆Hcy值分别为（13.75±5.43）、（15.26±9.72）和（15.55±9.12）μmol/L（P=0.001）;HHcy患病率分别为23.9%、40.5%和46.3%（P〈0.001）。吸烟组和不吸烟组Hcy水平分别为（16.14±8.05）和（14.60±8.31）μmol/L（P=0.037）,HHcy患病率分别为44.9%和34.2%（P=0.011）。高血压组和无高血压组Hcy水平分别为（15.24±9.72）和（14.20±6.42）μmol/L（P=0.012）,HHcy患病率分别为39.7%和30.3%（P〈0.001）。多因素Logistic回归分析表明,性别、年龄和高血压是HHcy的危险因素,优势比（odds ratio,OR）分别为1.92（95%CI为1.46-2.54,P〈0.001）、1.89（95%CI为1.55-2.29,P〈0.001）和1.57（95%CI为1.20-2.05,P=0.001）。结论上海大团社区老年人群中Hcy血浆水平存在性别、年龄差异,HHcy的危险因素包括性别、年龄和高血压。Objective To explore the prevalence and distribution characteristics of hyperhomocysteinemia（HHcy）of the elderly population in a rural community of Shanghai,and to analyze its related risk factors. Methods A cross-sectional survey on the level and distribution characteristics of plasma homocysteine（Hcy）was conducted in the elderly（≥60 years）in Datuan community of Shanghai.Multi-factor non-conditional logistic regression was used to analyze the risk factors of Hcy level.Results A total of 1 621 elderly people were enrolled in this study.The plasma Hcy level in the male was higher than that in the female,and the difference was statistically significant[（15.72± 9.22）μmol/Lvs.（14.08±7.55）μmol/L,P0.001],while the prevalence of HHcy in the male was higher than that in the female（43.6% vs.29.5%,P0.001）.The plasma Hcy levels in the different age groups of70 years,70-80 years and80 years were（13.75±5.43）,（15.26±9.72）and（15.55± 9.12）μmol/L（P=0.001）,while the prevalences of HHcy were 23.9%,40.5% and 46.3%,respectively（P0.001）.The plasma Hcy levels in the groups with and without smoke were（16.14±8.05）and（14.60±8.31）μmol/L（P=0.037）,while the prevalences of HHcy were 44.9% and34.2%,respectively（P=0.011）.The plasma Hcy levels in the groups with and without hypertension were（15.24±9.72）and（14.20±6.42）μmol/L（P=0.012）,while the prevalences of HHcy were39.7% and 30.3%,respectively（P0.001）.The Logistic regression showed that gender,age and hypertension were risk factors for HHcy with the odds ratio（OR）of 1.92（95%CI：1.46-2.54,P0.001）,1.89（95%CI：1.55-2.29,P0.001）and 1.57（95%CI：1.20-2.05,P=0.001）,respectively. Conclusions Plasma Hcy level had difference in gender and ages in the 1 621 elderly population in Datuan Community of Shanghai.The risk factors for HHcy included gender,age and hypertension.

关 键 词：上海 农村社区 老年人群 高同型半胱氨酸血症 危险因素 

分 类 号：R821.35[医药卫生—临床医学]