慢性乙型肝炎患者中IL-37的水平与HBeAg血清转换的关系研究  

Expression levels of IL-37 and HBeAg seroconversion in chronic HBV patients

作　　者：刘晶晶[1] 李庆彦[1] 管珊[1] 刘春华[1] 贺玉凯[1] 陶昌明 

机构地区：[1]聊城市人民医院感染科,聊城252000

出　　处：《中国免疫学杂志》2015年第11期1545-1548,1552,共5页Chinese Journal of Immunology

摘　　要：目的:观察HBeAg阳性的慢性乙型肝炎(CHB)患者在接受替比夫定抗病毒治疗期间外周血IL-37表达的变化与HBeAg血清学转换的关系。方法:选取2013年9月至2014年1月在我科住院HBeAg阳性的CHB患者50例,健康对照组20例为本院健康志愿者。检测各组血清中IL-37、IL-6、CRP的水平。并于0、12、24、36、48周动态观察IL-37表达的变化与HBeAg血清学转换的关系。结果:HBeAg阳性CHB患者血清中IL-37的表达水平显著高于对照组(q=22.716,P<0.01)。经抗病毒治疗后HBeAg血清学转换患者中IL-37的表达水平较治疗前明显下降(t=-19.480,P<0.001)。IL-37与ALT、IL-6、CRP呈正相关性(r分别为0.697,0.725,0.895,P均<0.001),与HBV DNA无相关性(r=0.136,P>0.05)。结论:在HBeAg阳性CHB患者中IL-37可能参与了HBV感染的过程,并能够反映肝脏炎症的程度。经过替比夫定抗病毒治疗后,IL-37可能参与了HBeAg血清学转换的过程。IL-37可作为慢性乙肝治疗的一个新指标。Objective： Detecting serum IL-37 concentrations and HBeAg seroconversion in chronic hepatitis B virus（ HBV） patients during the treatment of telbivudine（ LDT）. Methods： Fifty patients with chronic hepatitis B were included in the study; and 20 healthy people were selected as the control group. The expression levels of interleukin（ IL）-37,IL-6 and CRP were measured by enzyme-linked immunosorbent assay. As the same time,the relationship between serum IL-37 concentrations and HBeAg seroconversion was dynamically observed at 0 w,12 w,24 w,36 w,48 w after treatment. Results： The serum levels of IL-37 in chronic HBV patients were higher than the control group at baseline（ q = 22. 716,P0. 01）. The serum levels of IL-37 were decreased in HBeAg seroconverted CHB patients（ t =-19. 480,P〈0. 001）. The levels of IL-37 were positively correlated with ALT,IL-6 and CRP（ r were 0. 697,0. 725,0. 895,respectively; all P〈0. 001）. The levels of IL-37 and HBV DNA was no correlation（ r = 0. 136,P〉0. 05）. Conclusion： IL-37 may be involved in the process of HBV infection in CHB patients,and can reflect the degree of liver＇s inflammatory damage. IL-37 may play a significant role in the immune response of CHB patients with HBeAg seroconversion. In future,IL-37 may be an effective therapeutic measure to HBV infection.

关 键 词：慢性乙型肝炎 白细胞介素-37 替比夫定 HBEAG血清学转换 

分 类 号：R392[医药卫生—免疫学]